MOBKL1A

MOB1B
Identifiers
Aliases	MOB1B, MATS2, MOB4A, MOBKL1A, MOB kinase activator 1B
External IDs	OMIM: 609282; MGI: 1915723; HomoloGene: 61676; GeneCards: MOB1B; OMA:MOB1B - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	71,022,449 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	88,912,079 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; thymus; ; superior surface of tongue; ; saphenous vein; ; skin of arm; ; trabecular bone; ; Medulla Oblongata; ; trigeminal ganglion; ; superior vestibular nucleus; ; body of tongue;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; seminal vesicula; ; Epithelium of choroid plexus; ; left lobe of liver; ; aortic valve; ; ascending aorta; ; ciliary body; ; atrioventricular valve; ; epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase binding; protein binding; kinase activator activity; metal ion binding;
Cellular component	cytoplasm; extracellular exosome; nucleus; nucleolus; cytosol;
Biological process	regulation of protein autophosphorylation; hippo signaling; positive regulation of phosphorylation; positive regulation of kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	92597
	68473
	ENSG00000173542
	ENSMUSG00000006262
	Q7L9L4
	Q8BPB0
	NM_001244766; NM_001244767; NM_173468
	NM_026735
	NP_001231695; NP_001231696; NP_775739
	NP_081011
	Wikidata
View/Edit Human	View/Edit Mouse

Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.^[5]^[6]

Function

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173542 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006262 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MOB1".
^ Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (June 2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chow A, Hao Y, Yang X (2010). "Molecular characterization of human homologs of yeast MOB1". Int. J. Cancer. 126 (9): 2079–89. doi:10.1002/ijc.24878. hdl:1974/1468. PMID 19739119. S2CID 33688672.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

v t e Signaling pathway: Hippo signaling pathway
Receptor	FAT4
Adaptor protein	NF2 FRMD6 SAV1 MOBKL1A MOBKL1B
Kinase	MST1 LATS1 LATS2 STK3
Transcription factor	YAP1 TAZ
Other/unknown	RASSF1