INTS12

INTS12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WEV
Identifiers
Aliases	INTS12, INT12, PHF22, SBBI22, integrator complex subunit 12
External IDs	OMIM: 611355; MGI: 1919043; HomoloGene: 32474; GeneCards: INTS12; OMA:INTS12 - orthologs
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	132,816,749 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; right ventricle; ; islet of Langerhans; ; gastrocnemius muscle; ; jejunal mucosa; ; triceps brachii muscle; ; ganglionic eminence; ; biceps brachii; ; Achilles tendon;
	Top expressed in
	secondary oocyte; ; genital tubercle; ; zygote; ; primary oocyte; ; tail of embryo; ; granulocyte; ; otic placode; ; medial ganglionic eminence; ; epiblast; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	integrator complex; nucleoplasm; nucleus;
Biological process	snRNA processing; snRNA transcription by RNA polymerase II; snRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	57117
	71793
	n/a
	ENSMUSG00000028016
	Q96CB8
	Q9D168
	NM_001142471; NM_020395
	NM_027927
	NP_001135943; NP_065128; NP_001135943.1; NP_065128.2
	NP_082203
	Wikidata
View/Edit Human	View/Edit Mouse

Integrator complex subunit 12 (Int12) also known as PHD finger protein 22 (PHF22) is a protein that in humans is encoded by the INTS12 gene.^[4]

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2)^[4]^[5]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028016 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: integrator complex subunit 12". Retrieved 2011-08-30.
^ Baillat D, Hakimi MA, et al. (2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.

Kalsi G, Kuo PH, Aliev F, et al. (2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000028016 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: integrator complex subunit 12". Retrieved 2011-08-30.

[Baillat-5] Baillat D, Hakimi MA, et al. (2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.

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References

Further reading