ESX1

ESX1
Identifiers
Aliases	ESX1, ESX1L, ESXR1, ESX homeobox 1
External IDs	OMIM: 300154; HomoloGene: 49152; GeneCards: ESX1; OMA:ESX1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	104,254,933 bp
RNA expression pattern
	Top expressed in
	testicle; ; right testis; ; left testis; ; gonad; ; epithelium of colon; ; placenta; ; endometrium; ; human musculoskeletal system; ; muscular system; ; skeletal muscle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cytoplasm; nuclear speck;
Biological process	negative regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	80712
	n/a
	ENSG00000123576
	n/a
	Q8N693
	n/a
	NM_153448
	n/a
	NP_703149
	n/a
	Wikidata
View/Edit Human

Homeobox protein ESX1 is a protein that in humans is encoded by the ESX1 gene.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123576 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fohn LE, Behringer RR (May 2001). "ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis". Genomics. 74 (1): 105–8. doi:10.1006/geno.2001.6532. PMID 11374906.
^ Loschiavo M, Nguyen QK, Duselis AR, Vrana PB (Feb 2007). "Mapping and identification of candidate loci responsible for Peromyscus hybrid overgrowth". Mamm Genome. 18 (1): 75–85. doi:10.1007/s00335-006-0083-x. PMC 1794137. PMID 17242862.
^ "Entrez Gene: ESX1 extraembryonic, spermatogenesis, homeobox 1 homolog (mouse)".

Murthi P, Doherty VL, Said JM, et al. (2006). "Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction". Mol. Hum. Reprod. 12 (5): 335–40. doi:10.1093/molehr/gal037. PMID 16613891.
Figueiredo AL, Salles MG, Albano RM, Porto LC (2005). "Molecular and morphologic analyses of expression of ESX1L in different stages of human placental development". J. Cell. Mol. Med. 8 (4): 545–50. doi:10.1111/j.1582-4934.2004.tb00479.x. PMC 6740265. PMID 15601583.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ozawa H, Ashizawa S, Naito M, et al. (2004). "Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation". Oncogene. 23 (39): 6590–602. doi:10.1038/sj.onc.1207884. PMID 15235584.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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