AT-121

AT-121
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name 3-oxo-1'-(4-propan-2-ylcyclohexyl)-2-[2-(sulfamoylamino)ethyl]spiro[1H-isoquinoline-4,4'-piperidine];
CAS Number	2099681-31-7;
PubChem CID	129188444;
Chemical and physical data
Formula	C24H38N4O3S
Molar mass	462.65 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)[C@H]1CC[C@H](CC1)N1CCC2(CC1)C(=O)N(CCNS(N)(=O)=O)CC1=CC=CC=C21;

AT-121 is an experimental analgesic. It was designed to be bifunctional, acting as an agonist at both the μ-opioid receptor and the nociceptin receptor.^[1] The interaction with the nociceptin receptor is expected to block the abuse and dependence-related side effects that are typical of opioids.^[2] A study in nonhuman primates found that AT-121 has morphine-like analgesic effects, but suppressed the addictive effects.^[1]^[3]

References

^ ^a ^b Ding H, Kiguchi N, Yasuda D, Daga PR, Polgar WE, Lu JJ, et al. (August 2018). "A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates". Science Translational Medicine. 10 (456): eaar3483. doi:10.1126/scitranslmed.aar3483. PMC 6295194. PMID 30158150.
^ "Scientists take big step toward finding non-addictive painkiller". Science Daily. August 29, 2018.
^ "Study: Non-addictive painkiller is safe, effective in animals". UPI. August 30, 2018.

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[Ding-1] Ding H, Kiguchi N, Yasuda D, Daga PR, Polgar WE, Lu JJ, et al. (August 2018). "A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates". Science Translational Medicine. 10 (456): eaar3483. doi:10.1126/scitranslmed.aar3483. PMC 6295194. PMID 30158150.

[2] "Scientists take big step toward finding non-addictive painkiller". Science Daily. August 29, 2018.

[3] "Study: Non-addictive painkiller is safe, effective in animals". UPI. August 30, 2018.

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[2]

[3]

See also

References