ZNF598

ZNF598
Identifiers
Aliases	ZNF598, zinc finger protein 598, HEL2, zinc finger protein 598, E3 ubiquitin ligase
External IDs	OMIM: 617508; MGI: 2670965; HomoloGene: 5672; GeneCards: ZNF598; OMA:ZNF598 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,009,821 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,900,990 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; body of pancreas; ; skin of abdomen; ; sural nerve; ; minor salivary glands; ; granulocyte; ; anterior pituitary; ; right hemisphere of cerebellum; ; right lobe of liver; ; mucosa of transverse colon;
	Top expressed in
	gallbladder; ; superior surface of tongue; ; lactiferous gland; ; zygote; ; crypt of lieberkuhn of small intestine; ; Ileal epithelium; ; choroid plexus of fourth ventricle; ; secondary oocyte; ; primary oocyte; ; lip;
	More reference expression data
	n/a
Orthologs
	90850
	213753
	ENSG00000167962
	ENSMUSG00000041130
	Q86UK7
	Q80YR4
	NM_178167; NM_001405664; NM_001405665
	NM_183149; NM_001348231
	NP_835461
	NP_898972; NP_001335160
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 598 (ZNF598) is a protein that in humans is encoded by the ZNF598 gene.^[5]

Function

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex.^[6] The complex is thought to function as a translation repressor in embryonic development. ZNF598 and its yeast homologue Hel2 are ubiquitin ligases that ubiquitinate the 40S ribosomal subunit during ribosome-associated protein quality control.^[7]^[8]^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167962 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041130 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger protein 598".
^ Morita, Masahiro; Ler, Lian Wee; Fabian, Marc R.; Siddiqui, Nadeem; Mullin, Michael; Henderson, Valerie C.; Alain, Tommy; Fonseca, Bruno D.; Karashchuk, Galina; Bennett, Christopher F.; Kabuta, Tomohiro; Higashi, Shinji; Larsson, Ola; Topisirovic, Ivan; Smith, Robert J. (September 2012). "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development". Molecular and Cellular Biology. 32 (17): 3585–3593. doi:10.1128/MCB.00455-12. ISSN 1098-5549. PMC 3422012. PMID 22751931.
^ Juszkiewicz S, Hegde RS (February 2017). "Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination". Molecular Cell. 65 (4): 743–750.e4. doi:10.1016/j.molcel.2016.11.039. PMC 5316413. PMID 28065601.
^ Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ (February 2017). "ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation". Molecular Cell. 65 (4): 751–760.e4. doi:10.1016/j.molcel.2016.12.026. PMC 5321136. PMID 28132843.
^ Sitron CS, Park JH, Brandman O (May 2017). "Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation". RNA. 23 (5): 798–810. doi:10.1261/rna.060897.117. PMC 5393187. PMID 28223409.
^ Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T (July 2017). "Ubiquitination of stalled ribosome triggers ribosome-associated quality control". Nature Communications. 8 (1): 159. Bibcode:2017NatCo...8..159M. doi:10.1038/s41467-017-00188-1. PMC 5534433. PMID 28757607.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167962 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041130 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger protein 598".

[6] Morita, Masahiro; Ler, Lian Wee; Fabian, Marc R.; Siddiqui, Nadeem; Mullin, Michael; Henderson, Valerie C.; Alain, Tommy; Fonseca, Bruno D.; Karashchuk, Galina; Bennett, Christopher F.; Kabuta, Tomohiro; Higashi, Shinji; Larsson, Ola; Topisirovic, Ivan; Smith, Robert J. (September 2012). "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development". Molecular and Cellular Biology. 32 (17): 3585–3593. doi:10.1128/MCB.00455-12. ISSN 1098-5549. PMC 3422012. PMID 22751931.

[Juszkiewicz_Hegde_2017_pp._743–750.e4-7] Juszkiewicz S, Hegde RS (February 2017). "Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination". Molecular Cell. 65 (4): 743–750.e4. doi:10.1016/j.molcel.2016.11.039. PMC 5316413. PMID 28065601.

[Sundaramoorthy_Leonard_Mak_Liao_2017_pp._751–760.e4-8] Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ (February 2017). "ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation". Molecular Cell. 65 (4): 751–760.e4. doi:10.1016/j.molcel.2016.12.026. PMC 5321136. PMID 28132843.

[Sitron_Park_Brandman_pp._798–810-9] Sitron CS, Park JH, Brandman O (May 2017). "Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation". RNA. 23 (5): 798–810. doi:10.1261/rna.060897.117. PMC 5393187. PMID 28223409.

[Matsuo_Ikeuchi_Saeki_Iwasaki_p.-10] Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T (July 2017). "Ubiquitination of stalled ribosome triggers ribosome-associated quality control". Nature Communications. 8 (1): 159. Bibcode:2017NatCo...8..159M. doi:10.1038/s41467-017-00188-1. PMC 5534433. PMID 28757607.

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