Tritoqualine

Tritoqualine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	R06AX21 (WHO) ;
Identifiers
	IUPAC name 7-amino-4,5,6-triethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one;
CAS Number	14504-73-5;
PubChem CID	72145;
ChemSpider	65119;
UNII	F4MW5166YH;
CompTox Dashboard (EPA)	DTXSID10864514 ;
Chemical and physical data
Formula	C26H32N2O8
Molar mass	500.548 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC1=C(C(=C(C2=C1C(OC2=O)C3C4=C(C5=C(C=C4CCN3C)OCO5)OC)N)OCC)OCC;

Tritoqualine, also known as hypostamine, is an inhibitor of the enzyme histidine decarboxylase and therefore an atypical antihistamine, used for the treatment of urticaria and allergic rhinitis^[1] with no known adverse effects.^{[citation needed]}

References

^ Pradalier A, Hentschel V, Prouzeau S, Legallais D, Lefrancois G (April 2003). "Randomized, placebo controlled study of tritoqualine (hypostamine*) in the treatment of perennial allergic rhinitis". Revue Française d'Allergologie et d'Immunologie Clinique. 43 (3): 175–9. doi:10.1016/S0335-7457(03)00047-9.

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[1] Pradalier A, Hentschel V, Prouzeau S, Legallais D, Lefrancois G (April 2003). "Randomized, placebo controlled study of tritoqualine (hypostamine*) in the treatment of perennial allergic rhinitis". Revue Française d'Allergologie et d'Immunologie Clinique. 43 (3): 175–9. doi:10.1016/S0335-7457(03)00047-9.

[1]

v t e Antihistamines (R06)
Benzimidazoles (*)	Astemizole Azelastine Bilastine Emedastine Mizolastine Talastine
Diarylmethanes	Diarylmethoxyalkylamines: Bromazine (bromodiphenhydramine) Carbinoxamine Chlorphenoxamine Clemastine Diphenhydramine (+naproxen) Diphenylpyraline Doxylamine Ebastine Orphenadrine Diphenylmethanolpiperidines: Fexofenadine Terfenadine Diphenylmethylpiperazines: Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Etodroxizine Hydroxyzine Meclizine Oxatomide Phenylpyridinylpropanamines: Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Pheniramine Others: Acrivastine Bamipine Dimetindene Phenyltoloxamine Pyrrobutamine Quifenadine Triprolidine
Ethylenediamines	Antazoline Chloropyramine Histapyrrodine Mepyramine (pyrilamine) Methapyrilene Phenbenzamine Thenalidine Tripelennamine (pyribenzamine)
Tricyclics	Dibenzocycloheptenes: Antidepressants (e.g., amitriptyline) Azatadine Cyproheptadine Deptropine Desloratadine Ketotifen Loratadine Rupatadine Phenothiazines: Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Others: Antidepressants (e.g., doxepin, mirtazapine, trimipramine) Epinastine Latrepirdine Mebhydrolin Olopatadine Perlapine Phenindamine Pimethixene
Others	Phenylpiperazines: Antidepressants (e.g., trazodone) Phenbenzamine
For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Doxepin Isothipendyl Mepyramine (pyrilamine) Promethazine