Thiamine-diphosphate kinase
| thiamin diphosphate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.4.15 | ||||||||
| CAS no. | 9075-79-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a thiamine-diphosphate kinase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction
- thiamine diphosphate + ATP thiamine triphosphate + ADP
Thus, the two substrates of this enzyme are ATP and thiamine diphosphate, whereas its two products are ADP and thiamine triphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:thiamine-diphosphate phosphotransferase. Other names in common use include ATP:thiamin-diphosphate phosphotransferase, TDP kinase, thiamin diphosphate kinase, thiamin diphosphate phosphotransferase, thiamin pyrophosphate kinase, thiamine diphosphate kinase, and protein bound thiamin diphosphate:ATP phosphoryltransferase.
See also
[edit]References
[edit]- Itokawa Y, Cooper JR (1968). "The enzymatic synthesis of triphosphothiamin". Biochim. Biophys. Acta. 158 (1): 180–2. doi:10.1016/0304-4165(68)90093-7. PMID 5661031.
- Kikuchi M; Ikawa T. "Presence of an enzyme mediating transfer of phosphate from thiamine triphosphate to ADP in germinating maize". Bot. Mag. Tokyo: 193–205.
