Talk:Glutamate transporter

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Use the ref-tag! Example: <ref>author, paper, year etc.</ref>

Would someone adjust the table to show alternate names for the EAATs?

EAAT1=GLAST (Glutamate aspartate transporter)

EAAT2=GLT1 (glutamate transporter 1)

EAAT3=EAAC1 (neuronal versus astrocyte transporter)

• cite: O'Kane, R. L.; Martinez-Lopez, I.; DeJoseph, M. R.; Vina, J. R.; Hawkins, R. A. (5 November 1999). "Na+-dependent Glutamate Transporters (EAAT1, EAAT2, and EAAT3) of the Blood-Brain Barrier: A MECHANISM FOR GLUTAMATE REMOVAL". Journal of Biological Chemistry. 274 (45): 31891–31895. doi:10.1074/jbc.274.45.31891.{{cite journal}}: CS1 maint: unflagged free DOI (link)

(I'm just adding the names, and the above citation) I haven't read enough of the article to know where that citation might fit into the article though. Jimw338 (talk) 04:56, 14 July 2015 (UTC)[reply]

@Boghog: I went through all the entries in this NCBI gene search and found that there's 2 transporters (technically, only 1 notable transporter) that's not covered in the lead at the moment. xCT (SLC7A11) is a transporter which is primarily involved in the transport of cysteine anions and glutamate (NCBI gene entry for xCT). Sialin (SLC17A5) is a transporter that is primarily involved in the transport of sialic acids which appears to also transport glutamate and aspartate into synaptic vesicles in the hippocampus (PMID 18695252 - NCBI gene entry for sialin).

I have 3 questions for you:

1. I think xCT should be added to the table of proteins and be covered in the lead. However, since it's a member of SLC7, it belongs to a different solute carrier subfamily than EAATs (SLC1) and VGLUTs (SLC17), so should I state that this protein belongs to a 3rd subclass of glutamate transporters?
2. Should sialin be mentioned in this article? It doesn't really seem that notable since glutamate/aspartate transport isn't covered in much detail in the NCBI gene entry, but it does perform the same function as VGLUTs and belongs to the same solute carrier subfamily as them (SLC17).
3. Unrelated question: should we move the Glutamate transporter#VGluT3 section to VGLUT3? It seems more appropriate there.

Seppi333 (Insert 2¢) 23:53, 10 January 2017 (UTC)[reply]