Tropomodulin 2

TMOD2
Identifiers
Aliases	TMOD2, N-TMOD, NTMOD, tropomodulin 2
External IDs	OMIM: 602928; MGI: 1355335; HomoloGene: 22817; GeneCards: TMOD2; OMA:TMOD2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	51,816,363 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	75,518,607 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; lateral nuclear group of thalamus; ; primary visual cortex; ; entorhinal cortex; ; pars compacta; ; parietal lobe; ; external globus pallidus; ; postcentral gyrus;
	Top expressed in
	lateral septal nucleus; ; ventromedial nucleus; ; lateral geniculate nucleus; ; visual cortex; ; anterior amygdaloid area; ; primary visual cortex; ; lateral hypothalamus; ; mammillary body; ; primary motor cortex; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding; tropomyosin binding;
Cellular component	cytoplasm; growth cone; neuron projection; cytoskeleton; striated muscle thin filament; myofibril;
Biological process	pointed-end actin filament capping; positive regulation of G protein-coupled receptor signaling pathway; neuron-neuron synaptic transmission; nervous system development; learning or memory; muscle contraction; actin filament organization; myofibril assembly;
	Sources:Amigo / QuickGO
Orthologs
	29767
	50876
	ENSG00000128872
	ENSMUSG00000032186
	Q9NZR1
	Q9JKK7
	NM_014548; NM_001142885
	NM_001038710; NM_016711
	NP_001136357; NP_055363
	NP_001033799; NP_057920
	Wikidata
View/Edit Human	View/Edit Mouse

Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.^[5]

Function

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128872 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032186 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
^ "Entrez Gene: TMOD2, Tropomodulin 2 (neuronal)".

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer. 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301. S2CID 875146.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Watakabe A, Kobayashi R, Helfman DM (1996). "N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin". J. Cell Sci. 109 (9): 2299–310. doi:10.1242/jcs.109.9.2299. PMID 8886980.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128872 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032186 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10662549-5] Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.

[entrez-6] "Entrez Gene: TMOD2, Tropomodulin 2 (neuronal)".

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Function

References

Further reading