From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Inactive rhomboid protein 2 is a protein that in humans is encoded by the RHBDF2 gene .[ 5] [ 6] rhomboid family of intramembrane serine proteases .[ 7] [ 8]
The RHBDF2 gene is located on the long arm of chromosome 17 (17q25.1) on the Crick (minus) strand. It is 30.534 kilobases in length and encodes a protein of 856 amino acids with a predicted molecular weight of 96.686 kilodaltons.
The RHBDF2 protein plays an important role in the secretion of tumor necrosis factor alpha ,[ 9] [ 10] [ 11] esophageal cancer .[ 12]
It is involved in the regulation of the secretion of several ligands of the epidermal growth factor receptor .[ 13]
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