Propiverine

Propiverine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	G04BD06 (WHO) ;
Legal status
Legal status	CA: ℞-only;
Pharmacokinetic data
Elimination half-life	20.1 h
Identifiers
	IUPAC name 1-methylpiperidin-4-yl diphenyl(propoxy)acetate;
CAS Number	60569-19-9 ; HCl: 54556-98-8 ;
PubChem CID	4942;
ChemSpider	4773 ;
UNII	468GE2241L; HCl: DC4GZD10H3 ;
CompTox Dashboard (EPA)	DTXSID5048265 ;
Chemical and physical data
Formula	C23H29NO3
Molar mass	367.489 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C;
	InChI InChI=1S/C23H29NO3/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21/h4-13,21H,3,14-18H2,1-2H3 ; Key:QPCVHQBVMYCJOM-UHFFFAOYSA-N ;
	(what is this?) (verify)

Propiverine is an anticholinergic drug used for the treatment of urinary urgency, frequency and urge incontinence, all symptoms of overactive bladder syndrome.^[2]^[3] It is a muscarinic antagonist.^[4]

References

^ "Digestive and bladder health". Health Canada. 9 May 2018. Retrieved 13 April 2024.
^ McKeage K (January 2013). "Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms". Clinical Drug Investigation. 33 (1): 71–91. doi:10.1007/s40261-012-0046-9. PMID 23288694. S2CID 3399082.
^ Huang W, Zong H, Zhou X, Wang T, Zhang Y (December 2015). "Efficacy and Safety of Propiverine Hydrochloride for Overactive Bladder in Adult: a Systematic Review and Meta-analysis". The Indian Journal of Surgery. 77 (Suppl 3): 1369–1377. doi:10.1007/s12262-015-1264-1. PMC 4775592. PMID 27011567.
^ BNF 61. London: British Medical Journal Group and Pharmaceutical Press. March 2011. p. 511. ISBN 978-0-85369-962-0.

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[1] "Digestive and bladder health". Health Canada. 9 May 2018. Retrieved 13 April 2024.

[pmid23288694-2] McKeage K (January 2013). "Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms". Clinical Drug Investigation. 33 (1): 71–91. doi:10.1007/s40261-012-0046-9. PMID 23288694. S2CID 3399082.

[pmid27011567-3] Huang W, Zong H, Zhou X, Wang T, Zhang Y (December 2015). "Efficacy and Safety of Propiverine Hydrochloride for Overactive Bladder in Adult: a Systematic Review and Meta-analysis". The Indian Journal of Surgery. 77 (Suppl 3): 1369–1377. doi:10.1007/s12262-015-1264-1. PMC 4775592. PMID 27011567.

[4] BNF 61. London: British Medical Journal Group and Pharmaceutical Press. March 2011. p. 511. ISBN 978-0-85369-962-0.

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v t e Urologicals, including antispasmodics (G04B)
Acidifiers	Ammonium chloride Calcium chloride
Urinary antispasmodics (primarily antimuscarinics)	Darifenacin Desfesoterodine Emepronium Fesoterodine Flavoxate Imidafenacin Meladrazine Mirabegron Oxybutynin Propiverine Solifenacin Terodiline Tolterodine Trospium chloride Vibegron
Other urologicals	Urea analogues: Acetohydroxamic acid Salicylhydroxamic acid Other: Collagen Dapoxetine Dimethyl sulfoxide Magnesium hydroxide Pentosan polysulfate Phenazopyridine Phenyl salicylate Succinimide Tiopronin