Propagermanium

Propagermanium
Names
	IUPAC name 3-[(2-Carboxyethyl-oxogermyl)oxy-oxogermyl]propanoic acid
	Other names proxigermanium, Ge-132, germanium sesquioxide, 2-carboxyethylgermasesquioxane, SK-818, bis(2-carboxyethylgermanium) sesquioxide
Identifiers
CAS Number	12758-40-6 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:32060;
ChemSpider	74907;
ECHA InfoCard	100.032.533
EC Number	235-800-0;
KEGG	C13086; D01626;
PubChem CID	83030;
UNII	1Q2P9TO9Q7 ;
CompTox Dashboard (EPA)	DTXSID9065316 ;
	InChI InChI=1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,10)(H,11,12) Key: XEABSBMNTNXEJM-UHFFFAOYSA-N;
	SMILES C(C[Ge](=O)O[Ge](=O)CCC(=O)O)C(=O)O;
Properties
Chemical formula	C6H10O7Ge2
Molar mass	339.4222 g/mol
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H315, H319, H335
Precautionary statements	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Propagermanium (INN), also known by a variety of other names including bis(2-carboxyethylgermanium) sesquioxide and 2-carboxyethylgermasesquioxane, is an organometallic compound of germanium^[2] that is sold as an alternative medicine. It is a polymeric compound with the formula ((HOOCCH₂CH₂Ge)₂O₃)_n.

The compound was first synthesized in 1967 at the Asai Germanium Research Institute^[3] in Japan. It is a water-soluble organogermanium compound used as raw material in nutritional supplements. The compound displays low toxicity in studies with rats.^[4]

References

^ "Bis (2-Carboxyethylgermanium)sesquioxide". pubchem.ncbi.nlm.nih.gov.
^ M.P. Egorov, P.P. Gaspar (1994), Germanium: Organometallic chemistry in Encyclopedia of Inorganic Chemistry. John Wiley & Sons ISBN 0-471-93620-0
^ "Asai Germanium Japan". Asai Germanium Japan. Retrieved 2022-02-04.
^ Doi, Yuko; et al. (2017). "No carcinogenicity of poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132): 26-week feeding study using rasH2 mice". Fundamental Toxicological Sciences. 4 (3): 137–150. doi:10.2131/fts.4.137.

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[1] "Bis (2-Carboxyethylgermanium)sesquioxide". pubchem.ncbi.nlm.nih.gov.

[2] M.P. Egorov, P.P. Gaspar (1994), Germanium: Organometallic chemistry in Encyclopedia of Inorganic Chemistry. John Wiley & Sons ISBN 0-471-93620-0

[3] "Asai Germanium Japan". Asai Germanium Japan. Retrieved 2022-02-04.

[4] Doi, Yuko; et al. (2017). "No carcinogenicity of poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132): 26-week feeding study using rasH2 mice". Fundamental Toxicological Sciences. 4 (3): 137–150. doi:10.2131/fts.4.137.

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