LILRB5

LILRB5
Identifiers
Aliases	LILRB5, CD85C, LIR-8, LIR8, leukocyte immunoglobulin like receptor B5
External IDs	OMIM: 604814; HomoloGene: 134027; GeneCards: LILRB5; OMA:LILRB5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,257,301 bp
RNA expression pattern
	Top expressed in
	spleen; ; thymus; ; subcutaneous adipose tissue; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; placenta; ; duodenum; ; right coronary artery; ; gastric mucosa;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane;
Biological process	defense response; cell surface receptor signaling pathway; adaptive immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	10990
	n/a
ENSG00000274311; ENSG00000278437; ENSG00000273991; ENSG00000277414; ENSG00000105609;
	n/a
	n/a
	O75023
	n/a
	NM_001081442; NM_001081443; NM_001304457; NM_006840
	n/a
	NP_001074911; NP_001074912; NP_001291386; NP_006831
	n/a
	Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.^[3]^[4]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.^[4]

References

^ ^a ^b ^c ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 GRCh38: Ensembl release 89: ENSG00000274311, ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.
^ ^a ^b "Entrez Gene: LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5".

Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 GRCh38: Ensembl release 89: ENSG00000274311, ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9548455-3] Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.

[entrez-4] "Entrez Gene: LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5".

[1]

[2]

[3]

[4]

References

Further reading