Oscillation (cell signaling)

Oscillations are an important type of cell signaling characterized by the periodic change of the system in time.^[1] Oscillations can take place in a biological system in a multitude of ways. Positive feedback loops, on their own or in combination with negative feedback are a common feature of oscillating biological systems.^[2]

Examples

Genetic oscillation

One of the most common forms of biological oscillation is genetic oscillation, which can take place when a transcription factor binds and represses its own promoter. This type of regulatory system is able to successfully describe the NFkB-IkB and p53-Mdm52 biological oscillating systems.^[1]

Relaxation oscillations

Relaxation oscillation takes place in the context of a bi-stable system. It is characterized by the periodic switching between two stable states.^[2]

References

^ ^a ^b Kruse & Jülicher. Oscillations in Biology. 2005
^ ^a ^b Kholodenko. Cell-signaling dynamics in time and space. 2006

[Kruse_&_Jülicher._Oscillations_in_Biology._2005-1] Kruse & Jülicher. Oscillations in Biology. 2005

[Kholodenko._Cell-signaling_dynamics_in_time_and_space._2006-2] Kholodenko. Cell-signaling dynamics in time and space. 2006

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