DGKB

DGKB
Identifiers
Aliases	DGKB, DAGK2, DGK, DGK-BETA, diacylglycerol kinase beta
External IDs	OMIM: 604070; MGI: 2442474; HomoloGene: 37875; GeneCards: DGKB; OMA:DGKB - orthologs
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	38,684,238 bp
RNA expression pattern
	n/a
	Top expressed in
	dorsal striatum; ; olfactory tubercle; ; mammillary body; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; piriform cortex; ; globus pallidus; ; nucleus accumbens; ; lateral septal nucleus; ; temporal lobe;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; calcium ion binding; ATP binding; metal ion binding; kinase activity; diacylglycerol kinase activity; NAD+ kinase activity;
Cellular component	cytoplasm; nucleus; cytosol; plasma membrane; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	platelet activation; protein kinase C-activating G protein-coupled receptor signaling pathway; intracellular signal transduction; phosphorylation; glycerolipid metabolic process; lipid phosphorylation; metabolism; signal transduction; response to bacterium; modulation of chemical synaptic transmission; regulation of postsynapse organization; diacylglycerol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1607
	217480
	ENSG00000136267
	ENSMUSG00000036095
	Q9Y6T7
	Q6NS52
	NM_004080; NM_145695
	NM_178681; NM_001361686; NM_001361688
NP_663733; NP_001337634; NP_001337635; NP_001337636; NP_001337637;
	NP_001337638; NP_001337640; NP_001337641; NP_001337643; NP_001337644; NP_001337645; NP_001337646; NP_001337647; NP_001337648; NP_001337649; NP_001337650; NP_001337651; NP_001337652; NP_001337653
	NP_848796; NP_001348615; NP_001348617
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.^[4]^[5]

Function

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.^[5]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036095 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Goto K, Kondo H (August 1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons". Proceedings of the National Academy of Sciences of the United States of America. 90 (16): 7598–602. Bibcode:1993PNAS...90.7598G. doi:10.1073/pnas.90.16.7598. PMC 47189. PMID 7689223.
^ ^a ^b "Entrez Gene: DGKB diacylglycerol kinase, beta 90kDa".

Caricasole A, Bettini E, Sala C, Roncarati R, Kobayashi N, Caldara F, Goto K, Terstappen GC (February 2002). "Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties". The Journal of Biological Chemistry. 277 (7): 4790–6. doi:10.1074/jbc.M110249200. PMID 11719522.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000036095 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7689223-4] Goto K, Kondo H (August 1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons". Proceedings of the National Academy of Sciences of the United States of America. 90 (16): 7598–602. Bibcode:1993PNAS...90.7598G. doi:10.1073/pnas.90.16.7598. PMC 47189. PMID 7689223.

[entrez-5] "Entrez Gene: DGKB diacylglycerol kinase, beta 90kDa".

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Function

References

Further reading