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DEFA4

From Wikipedia, the free encyclopedia
DEFA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDEFA4, DEF4, HNP-4, HP-4, HP4, defensin alpha 4
External IDsOMIM: 601157; MGI: 3711900; HomoloGene: 48059; GeneCards: DEFA4; OMA:DEFA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001925

NM_001177481

RefSeq (protein)

NP_001916

NP_001170952

Location (UCSC)Chr 8: 6.94 – 6.94 MbChr 8: 21.56 – 21.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Defensin, alpha 4 (DEFA4), also known as neutrophil defensin 4 or HNP4, is a human defensin peptide that is encoded by the DEFA4 gene.[5][6] HNP4 is expressed in the granules of the neutrophil where it defends the host against bacteria[7] and viruses.[8]

Function

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Defensins are a peptide family of cytotoxic microbicides involved in innate immunity.[9] Members of the defensin family are distinguished by a conserved six-cysteine motif. Several human alpha defensin genes including HNP4 are clustered on chromosome 8. DEFA4 differs from other defensin genes by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. HNP4 inhibits corticotropin-stimulated corticosterone production.[5]

References

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  1. ^ a b c ENSG00000285318 GRCh38: Ensembl release 89: ENSG00000164821, ENSG00000285318Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061845Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: DEFA4; defensin, alpha 4, corticostatin (Homo sapiens)".
  6. ^ Wu Z, Ericksen B, Tucker K, Lubkowski J, Lu W (September 2004). "Synthesis and characterization of human alpha-defensins 4-6". The Journal of Peptide Research. 64 (3): 118–25. doi:10.1111/j.1399-3011.2004.00179.x. PMID 15317502.
  7. ^ Ericksen B, Wu Z, Lu W, Lehrer RI (January 2005). "Antibacterial activity and specificity of the six human {alpha}-defensins". Antimicrobial Agents and Chemotherapy. 49 (1): 269–75. doi:10.1128/AAC.49.1.269-275.2005. PMC 538877. PMID 15616305.
  8. ^ Wu Z, Cocchi F, Gentles D, Ericksen B, Lubkowski J, Devico A, et al. (January 2005). "Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro". FEBS Letters. 579 (1): 162–6. doi:10.1016/j.febslet.2004.11.062. PMID 15620707. S2CID 84062495.
  9. ^ Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI (October 1985). "Defensins. Natural peptide antibiotics of human neutrophils". The Journal of Clinical Investigation. 76 (4): 1427–35. doi:10.1172/JCI112120. PMC 424093. PMID 2997278.

Further reading

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