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Protein-coding gene in the species Homo sapiens
Docking protein 5 is a protein that in humans is encoded by the DOK5 gene .[ 5] [ 6]
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.[ 6]
DOK5 has been shown to interact with RET proto-oncogene .[ 5] [ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000101134 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027560 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF) . J Cell Biol . 154 (2): 345–54. doi :10.1083/jcb.200102032 . PMC 2150770 PMID 11470823 . ^ a b "Entrez Gene: DOK5 docking protein 5" .^ Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth" . J. Biol. Chem . 279 (40): 42072–81. doi :10.1074/jbc.M403726200 PMID 15286081 .
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