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Alexander Bachmanov

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Alexander A. Bachmanov
Born
Russian Federation
Alma materSaint Petersburg Veterinary Institute, Pavlov Institute of Physiology, Cambridge University
Known forTaste; Behavioral genetics
Scientific career
FieldsGenetics, physiology, neuroscience
InstitutionsPavlov Institute of Physiology Monell Chemical Senses Center GSK
Academic advisorsGary Beauchamp

Dr. Alexander Bachmanov studied veterinary medicine at the Saint Petersburg Veterinary Institute, Russia (1977-1982), received his Ph.D. in biological sciences from the Pavlov Institute of Physiology in Saint Petersburg, Russia in 1990. He completed postdoctoral fellowships at the Physiological Laboratory at Cambridge University in 1993 and at the Monell Chemical Senses Center, Philadelphia, Pennsylvania, in the United States from 1994 to 1997. He later joined Monnell's faculty.

Career and research

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His research at the Monell Chemical Senses Center focused on the genetics of taste, ingestive behavior, alcohol intake, metabolism and obesity. Bachmanov and his collaborators pioneered using the positional cloning approach to identify genes influencing behavior. Their identification of the mouse saccharin preference (Sac) genetic locus as a gene encoding the TAS1R3 taste receptor[1] was the first successful positional cloning of a behavioral quantitative trait locus (QTL). They have mapped several mouse QTLs for alcohol consumption[2][3] and obesity.[4][5][6] To discover novel genes involved in taste, they used transcriptomic[7] and genetic engineering[8] approaches.

In 2017, Bachmanov joined GSK, located in Collegeville, Pennsylvania, to work on pre-clinical drug discovery and development.

Select publications

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  • Bachmanov AA, Kiefer SW, Molina JC, Tordoff MG, Duffy VB, Bartoshuk LM, Mennella JA (2003) Chemosensory factors influencing alcohol perception, preferences and consumption. Alcoholism: Clinical and Experimental Research 27 (2): 220-231.
  • Bachmanov AA, Beauchamp GK (2007). Taste Receptor Genes. Annual Review of Nutrition 27:389-414.
  • Boughter JD, Bachmanov AA (2008) Genetics and Evolution of Taste. In: Basbaum AI, Kaneko A, Shepherd GM, Westheimer G (eds), The Senses: A Comprehensive Reference, Vol. 4 (Firestein S, Beauchamp GK eds), Olfaction and Taste. Elsevier/Academic Press, San Diego, CA. P. 371–390.
  • Bachmanov, Alexander A; Boughter, John D (2012). Genetics of Taste Perception. doi:10.1002/9780470015902.a0023587. ISBN 978-0470016176. {{cite book}}: |journal= ignored (help)
  • Bachmanov, AA; Bosak, NP; Lin, C; Matsumoto, I; Ohmoto, M; Reed, DR; Nelson, TM (2014). "Genetics of taste receptors". Curr Pharm Des. 20 (16): 2669–83. doi:10.2174/13816128113199990566. PMC 4764331. PMID 23886383.
  • Bachmanov, AA; Bosak, NP; Glendinning, JI; Inoue, M; Li, X; Manita, S; McCaughey, SA; Murata, Y; Reed, DR; Tordoff, MG; Beauchamp, GK (2016). "Genetics of Amino Acid Taste and Appetite". Adv Nutr. 7 (4): 806S–22S. doi:10.3945/an.115.011270. PMC 4942865. PMID 27422518.

References

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  1. ^ Bachmanov, Alexander A.; Li, Xia; Reed, Danielle R.; Ohmen, Jeffery D.; Li, Shanru; Chen, Zhenyu; Tordoff, Michael G.; de Jong, Pieter J.; Wu, Chenyan (2001). "Positional cloning of the mouse saccharin preference (Sac) locus". Chemical Senses. 26 (7): 925–933. doi:10.1093/chemse/26.7.925. ISSN 0379-864X. PMC 3644801. PMID 11555487.
  2. ^ Bachmanov, A. A.; Reed, D. R.; Tordoff, M. G.; Price, R. A.; Beauchamp, G. K. (1996). "Intake of Ethanol, Sodium Chloride, Sucrose, Citric Acid, and Quinine Hydrochloride Solutions by Mice: A Genetic Analysis". Behavior Genetics. 26 (6): 563–573. doi:10.1007/bf02361229. ISSN 0001-8244. PMC 3661408. PMID 8990535.
  3. ^ Bachmanov, Alexander A.; Reed, Danielle R.; Li, Xia; Li, Shanru; Beauchamp, Gary K.; Tordoff, Michael G. (2002). "Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross". Genome Research. 12 (8): 1257–1268. doi:10.1101/gr.129702. ISSN 1088-9051. PMC 186641. PMID 12176933.
  4. ^ Reed, Danielle R.; Li, Xia; McDaniel, Amanda H.; Lu, Ke; Li, Shanru; Tordoff, Michael G.; Price, R. Arlen; Bachmanov, Alexander A. (2003). "Loci on Chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains". Mammalian Genome. 14 (5): 302–313. doi:10.1007/s00335-002-2170-y. ISSN 0938-8990. PMC 1435867. PMID 12856282.
  5. ^ Reed, Danielle R.; McDaniel, Amanda H.; Li, Xia; Tordoff, Michael G.; Bachmanov, Alexander A. (2006). "Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice". Mammalian Genome. 17 (11): 1065–1077. doi:10.1007/s00335-006-0054-2. ISSN 0938-8990. PMC 1702371. PMID 17103053.
  6. ^ Lin, Cailu; Theodorides, Maria L.; McDaniel, Amanda H.; Tordoff, Michael G.; Zhang, Qinmin; Li, Xia; Bosak, Natalia; Bachmanov, Alexander A.; Reed, Danielle R. (2013). "QTL Analysis of Dietary Obesity in C57BL/6byj X 129P3/J F2 Mice: Diet- and Sex-Dependent Effects". PLOS ONE. 8 (7): e68776. Bibcode:2013PLoSO...868776L. doi:10.1371/journal.pone.0068776. ISSN 1932-6203. PMC 3726688. PMID 23922663.
  7. ^ Sukumaran, Sunil K.; Lewandowski, Brian C.; Qin, Yumei; Kotha, Ramana; Bachmanov, Alexander A.; Margolskee, Robert F. (2017). "Whole transcriptome profiling of taste bud cells". Scientific Reports. 7 (1): 7595. Bibcode:2017NatSR...7.7595S. doi:10.1038/s41598-017-07746-z. ISSN 2045-2322. PMC 5548921. PMID 28790351.
  8. ^ Nelson, Theodore M.; LopezJimenez, Nelson D.; Tessarollo, Lino; Inoue, Masashi; Bachmanov, Alexander A.; Sullivan, Susan L. (2010). "Taste Function in Mice with a Targeted Mutation of the Pkd1l3 Gene". Chemical Senses. 35 (7): 565–577. doi:10.1093/chemse/bjq070. ISSN 0379-864X. PMC 2924428. PMID 20605874.
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