AVN-101

AVN-101
Identifiers
	IUPAC name 2,8-Dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;
CAS Number	1025725-91-0 ; 1061354-48-0 (hydrochloride);
ChemSpider	24643855;
UNII	6MHR5IV28S;
ChEMBL	ChEMBL592752;
CompTox Dashboard (EPA)	DTXSID901032403 ;
Chemical and physical data
Formula	C21H24N2
Molar mass	304.437 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ccc2c(c1)c3c(n2CCc4ccccc4)CCN(C3)C;
	InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3; Key:IBUHDDLETPJVGP-UHFFFAOYSA-N;

Maritupirdine (developmental code name AVN-101), a close structural analogue of latrepirdine, is a selective 5-HT₆ receptor antagonist which is under development by Avineuro Pharmaceuticals for the treatment of Alzheimer's disease and anxiety disorders.^[1]^[2]^[3] As of November 2013, it was in phase II clinical trials for these indications.^[2]^[3]^[4]^{[needs update]}

It was approved in Russia on May 31, 2023 under the brand name Aviandr for the treatment of generalized anxiety disorder, mild-to-moderate anxiety conditions (stress reactions and adjustment disorders) and anxiety after COVID-19.^[5]

References

^ Ivachtchenko V, Ivanenkov Y (2013). "Small Molecule 5-HT6R Ligands: A Comprehensive Insight into their Selectivity and Activity". Current Bioactive Compounds. 9 (1): 64–100. doi:10.2174/1573407211309010007. ISSN 1573-4072.
^ ^a ^b Griebel G, Holmes A (September 2013). "50 years of hurdles and hope in anxiolytic drug discovery". Nature Reviews. Drug Discovery. 12 (9): 667–87. doi:10.1038/nrd4075. PMC 4176700. PMID 23989795.
^ ^a ^b Benhamú B, Martín-Fontecha M, Vázquez-Villa H, Pardo L, López-Rodríguez ML (September 2014). "Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease". Journal of Medicinal Chemistry. 57 (17): 7160–81. doi:10.1021/jm5003952. PMID 24850589.
^ "AVN 101". AdisInsight. Retrieved 2015-06-10.
^ "Aviandr (2,8-dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride) film-coated tablets. Full prescribing information". Russian State Register of Medicines (in Russian). Avineuro Pharmaceuticals, Inc.

External links

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[V._IvachtchenkoA._Ivanenkov2013-1] Ivachtchenko V, Ivanenkov Y (2013). "Small Molecule 5-HT6R Ligands: A Comprehensive Insight into their Selectivity and Activity". Current Bioactive Compounds. 9 (1): 64–100. doi:10.2174/1573407211309010007. ISSN 1573-4072.

[GriebelHolmes2013-2] Griebel G, Holmes A (September 2013). "50 years of hurdles and hope in anxiolytic drug discovery". Nature Reviews. Drug Discovery. 12 (9): 667–87. doi:10.1038/nrd4075. PMC 4176700. PMID 23989795.

[BenhamúMartín-Fontecha2014-3] Benhamú B, Martín-Fontecha M, Vázquez-Villa H, Pardo L, López-Rodríguez ML (September 2014). "Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease". Journal of Medicinal Chemistry. 57 (17): 7160–81. doi:10.1021/jm5003952. PMID 24850589.

[AdisInsight-4] "AVN 101". AdisInsight. Retrieved 2015-06-10.

[5] "Aviandr (2,8-dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride) film-coated tablets. Full prescribing information". Russian State Register of Medicines (in Russian). Avineuro Pharmaceuticals, Inc.

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[2]

[3]

[4]

[5]

v t e Psychoanaleptics: Anti-dementia agents (ATC code N06D and others)
AChE inhibitor medications	Benzgalantamine Donepezil (+memantine) Galantamine Ipidacrine Rivastigmine Tacrine
Other medications	Aducanumab Bifemelane Donanemab Ginkgo folium Lecanemab Meclofenoxate (centrophenoxine) Memantine (+donepezil) Nicergoline
Experimental BACE inhibitors	Lanabecestat Verubecestat

See also

References

External links