CACUL1

CACUL1
Identifiers
Aliases	CACUL1, C10orf46, CAC1, CDK2 associated cullin domain 1
External IDs	MGI: 1926082; HomoloGene: 17821; GeneCards: CACUL1; OMA:CACUL1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	118,755,249 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	60,569,463 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; epithelium of nasopharynx; ; cardiac muscle tissue of right atrium; ; amniotic fluid; ; gingival epithelium; ; pancreatic epithelial cell; ; endothelial cell; ; myocardium of left ventricle; ; germinal epithelium; ; parietal pleura;
	Top expressed in
	spermatid; ; seminiferous tubule; ; tail of embryo; ; arcuate nucleus; ; median eminence; ; extensor digitorum longus muscle; ; cingulate gyrus; ; plantaris muscle; ; stroma of bone marrow; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein kinase binding; ubiquitin protein ligase binding; ubiquitin protein ligase activity;
Cellular component	cullin-RING ubiquitin ligase complex;
Biological process	cell cycle; ubiquitin-dependent protein catabolic process; positive regulation of cell population proliferation; positive regulation of protein kinase activity; G1/S transition of mitotic cell cycle; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	143384
	78832
	ENSG00000151893
	ENSMUSG00000033417
	Q86Y37
	Q8R0X2
	NM_153810
	NM_001172096; NM_001172097; NM_030197
	NP_722517
	NP_001165567; NP_001165568; NP_084473
	Wikidata
View/Edit Human	View/Edit Mouse

CDK2 associated cullin domain 1 is a protein that in humans is encoded by the CACUL1 gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151893 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033417 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CDK2 associated cullin domain 1". Retrieved 2018-01-05.

Kong Y, Nan K, Yin Y (2009). "Identification and characterization of CAC1 as a novel CDK2-associated cullin". Cell Cycle. 8 (21): 3552–61. doi:10.4161/cc.8.21.9955. PMID 19829063.
Kong Y, Bai PS, Sun H, Nan KJ (2012). "Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients". J. Mol. Neurosci. 47 (2): 207–18. doi:10.1007/s12031-012-9717-5. PMID 22415352. S2CID 14719772.
Kong Y, Bai PS, Sun H, Nan KJ, Chen NZ, Qi XG (2012). "The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer". Int. J. Biochem. Cell Biol. 44 (12): 2321–32. doi:10.1016/j.biocel.2012.08.006. PMID 22903020.
Moon M, Um SJ, Kim EJ (2012). "CAC1 negatively regulates RARα activity through cooperation with HDAC". Biochem. Biophys. Res. Commun. 427 (1): 41–6. doi:10.1016/j.bbrc.2012.08.142. PMID 22982681.
Kim J, Park UH, Moon M, Um SJ, Kim EJ (2013). "Negative regulation of ERα by a novel protein CAC1 through association with histone demethylase LSD1". FEBS Lett. 587 (1): 17–22. doi:10.1016/j.febslet.2012.10.054. PMID 23178685. S2CID 207659623.
Zheng Q, Zhao LY, Kong Y, Nan KJ, Yao Y, Liao ZJ (2013). "CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line". World J Surg Oncol. 11: 5. doi:10.1186/1477-7819-11-5. PMC 3585504. PMID 23311997.
Chen TJ, Gao F, Yang T, Thakur A, Ren H, Li Y, Zhang S, Wang T, Chen MW (2013). "CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells". Biochem. Biophys. Res. Commun. 437 (1): 108–13. doi:10.1016/j.bbrc.2013.06.048. PMID 23806693.
Kong Y, Ma LQ, Bai PS, Da R, Sun H, Qi XG, Ma JQ, Zhao RM, Chen NZ, Nan KJ (2013). "Helicobacter pylori promotes invasion and metastasis of gastric cancer cells through activation of AP-1 and up-regulation of CACUL1". Int. J. Biochem. Cell Biol. 45 (11): 2666–78. doi:10.1016/j.biocel.2013.08.015. PMID 24004834.
Ma HL, Wen XP, Zhang XZ, Wang XL, Zhao DL, Che SM, Dang CX (2015). "miR-106a* inhibits the proliferation of esophageal carcinoma cells by targeting CDK2-associated Cullin 1 (CACUL1)". Cell. Mol. Biol. (Noisy-le-grand). 61 (4): 56–62. PMID 26314198.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151893 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033417 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CDK2 associated cullin domain 1". Retrieved 2018-01-05.

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References

Further reading