CACNG1

CACNG1
Identifiers
Aliases	CACNG1, CACNLG, calcium voltage-gated channel auxiliary subunit gamma 1
External IDs	OMIM: 114209; MGI: 1206582; HomoloGene: 582; GeneCards: CACNG1; OMA:CACNG1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	67,056,797 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	107,607,348 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; triceps brachii muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; skeletal muscle tissue; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; glutes; ; thoracic diaphragm;
	Top expressed in
	muscle of thigh; ; masseter muscle; ; temporal muscle; ; extensor digitorum longus muscle; ; ankle; ; medial head of gastrocnemius muscle; ; plantaris muscle; ; quadriceps femoris muscle; ; tibialis anterior muscle; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	voltage-gated calcium channel activity; protein binding; voltage-gated ion channel activity; calcium channel activity; calcium channel regulator activity;
Cellular component	voltage-gated calcium channel complex; integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; T-tubule; sarcolemma; L-type voltage-gated calcium channel complex;
Biological process	regulation of ion transmembrane transport; muscle contraction; ion transport; calcium ion transmembrane transport; sarcoplasmic reticulum calcium ion transport; calcium ion transport; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	786
	12299
	ENSG00000108878
	ENSMUSG00000020722
	Q06432
	O70578
	NM_000727
	NM_007582
	NP_000718
	NP_031608
	Wikidata
View/Edit Human	View/Edit Mouse

Voltage-dependent calcium channel gamma-1 subunit is a protein that in humans is encoded by the CACNG1 gene.^[5]^[6]

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108878 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020722 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Iles DE, Segers B, Sengers RC, Monsieurs K, Heytens L, Halsall PJ, Hopkins PM, Ellis FR, Hall-Curran JL, Stewart AD, et al. (Oct 1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility". Hum Mol Genet. 2 (7): 863–8. doi:10.1093/hmg/2.7.863. PMID 8395940.
^ ^a ^b "Entrez Gene: CACNG1 calcium channel, voltage-dependent, gamma subunit 1".

External links

CACNG1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CACNG1 genome location and CACNG1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108878 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020722 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8395940-5] Iles DE, Segers B, Sengers RC, Monsieurs K, Heytens L, Halsall PJ, Hopkins PM, Ellis FR, Hall-Curran JL, Stewart AD, et al. (Oct 1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility". Hum Mol Genet. 2 (7): 863–8. doi:10.1093/hmg/2.7.863. PMID 8395940.

[entrez-6] "Entrez Gene: CACNG1 calcium channel, voltage-dependent, gamma subunit 1".

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CACNG1

See also

References

Further reading

External links