KRT33A

KRT33A
Identifiers
Aliases	KRT33A, HA3I, Ha-3I, K33A, KRTHA3A, Krt1-3, hHa3-I, keratin 33A
External IDs	OMIM: 602761; MGI: 1919138; HomoloGene: 135742; GeneCards: KRT33A; OMA:KRT33A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,350,828 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,907,038 bp
RNA expression pattern
	Top expressed in
	testicle; ; mucosa of esophagus; ; left testis; ; right testis; ; skin of abdomen; ; vagina; ; skin of leg; ; minor salivary glands; ; right lung; ; ectocervix;
	Top expressed in
	lip; ; hair follicle; ; skin of back; ; dermis; ; skin of external ear; ; skin of abdomen; ; sexually immature organism; ; medial head of gastrocnemius muscle; ; conjunctival fornix; ; diencephalon;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity;
Cellular component	intermediate filament; extracellular space; cytosol;
Biological process	keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3883
	71888
	ENSG00000261986; ENSG00000006059
	ENSMUSG00000035592
	O76009
	Q8K0Y2
	NM_004138
	NM_027983
	NP_004129
	NP_082259
	Wikidata
View/Edit Human	View/Edit Mouse

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Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q21.2 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, KRT33A (this gene) and KRT33B.^[7]

References

^ ^a ^b ^c ENSG00000006059 GRCh38: Ensembl release 89: ENSG00000261986, ENSG00000006059 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035592 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rogers MA, Schweizer J, Kreig T, Winter H (Nov 1995). "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms". Mol Biol Rep. 20 (3): 155–61. doi:10.1007/BF00990548. PMID 7565656. S2CID 24487602.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT33A keratin 33A".

Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Rogers MA, Winter H, Langbein L, et al. (2005). "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain". Differentiation. 72 (9–10): 527–40. doi:10.1111/j.1432-0436.2004.07209006.x. PMID 15617563.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
Rogers MA, Winter H, Wolf C, et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J. Biol. Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000006059 GRCh38: Ensembl release 89: ENSG00000261986, ENSG00000006059 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035592 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7565656-5] Rogers MA, Schweizer J, Kreig T, Winter H (Nov 1995). "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms". Mol Biol Rep. 20 (3): 155–61. doi:10.1007/BF00990548. PMID 7565656. S2CID 24487602.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[entrez-7] "Entrez Gene: KRT33A keratin 33A".

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References

Further reading