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{{Infobox protein family
| Symbol = HECT
| Name = HECT-domain (ubiquitin-transferase) 
| image = PDB 1d5f EBI.jpg
| width = 
| caption = structure of an e6ap-ubch7 complex: insights into the ubiquitination pathway
| Pfam = PF00632
| Pfam_clan =  
| InterPro = IPR000569
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 1d5f
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}
In molecular biology, the '''HECT domain''' is a [[protein domain]] found in [[ubiquitin-protein ligases]]. The name HECT comes from ''''H'''omologous to the '''E'''6-AP '''C'''arboxyl '''T'''erminus'.<ref name="pmid7708685">{{cite journal |vauthors=Huibregtse JM, Scheffner M, Beaudenon S, Howley PM | title = A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 7 | pages = 2563–7 |date=March 1995 | pmid = 7708685 | pmc = 42258 | doi = 10.1073/pnas.92.7.2563| bibcode = 1995PNAS...92.2563H | doi-access = free }}</ref> [[Protein]]s containing this domain at the [[C terminus]] include [[ubiquitin-protein ligase]], which regulates [[ubiquitination]] of [[Cdc25|CDC25]]. Ubiquitin-protein ligase accepts [[ubiquitin]] from an [[ubiquitin-conjugating enzyme|E2 ubiquitin-conjugating enzyme]] in the form of a [[thioester]], and then directly transfers the ubiquitin to targeted [[substrate (biochemistry)|substrates]]. A [[cysteine]] residue is required for ubiquitin-thioester formation. Human thyroid receptor interacting protein 12 ([[TRIP12]]), which also contains this domain, is a component of an [[Adenosine triphosphate|ATP]]-dependent multisubunit protein that [[Protein-protein interaction|interact]]s with the [[ligand binding]] domain of the [[thyroid hormone receptor]]. It could be an E3 ubiquitin-protein ligase. Human [[E6AP|E6AP ubiquitin-protein ligase]] [[Protein-protein interaction|interact]]s with the E6 protein of the cancer-associated [[Human papillomavirus]] type 16 and Human papillomavirus type 18. The E6/E6-AP [[Protein complex|complex]] [[Molecular binding|bind]]s to and targets the [[p53]] [[Tumour suppressor gene|tumour-suppressor]] protein for ubiquitin-mediated [[proteolysis]].

==References==
{{reflist}}
{{InterPro content|IPR000569}}

[[Category:Protein domains]]

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