GMPPB

GMPPB
Identifiers
Aliases	GMPPB, MDDGA14, MDDGB14, MDDGC14, GDP-mannose pyrophosphorylase B, LGMDR19
External IDs	OMIM: 615320; MGI: 2660880; HomoloGene: 5578; GeneCards: GMPPB; OMA:GMPPB - orthologs
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,930,000 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; anterior pituitary; ; bone marrow cells; ; right lobe of thyroid gland; ; minor salivary glands; ; right lobe of liver; ; left lobe of thyroid gland; ; right adrenal gland; ; left adrenal gland; ; body of stomach;
	Top expressed in
	epithelium of small intestine; ; intestinal villus; ; Ileal epithelium; ; jejunum; ; duodenum; ; islet of Langerhans; ; spermatid; ; proximal tubule; ; placenta; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; mannose-1-phosphate guanylyltransferase activity; nucleotide binding; nucleotidyltransferase activity; GTP binding; protein binding;
Cellular component	cytoplasm;
Biological process	biosynthesis; GDP-mannose biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	29925
	331026
	n/a
	ENSMUSG00000070284
	Q9Y5P6
	Q8BTZ7
	NM_021971; NM_013334
	NM_177910; NM_001357682
	NP_037466; NP_068806
	NP_808578; NP_001344611
	Wikidata
View/Edit Human	View/Edit Mouse

Mannose-1-phosphate guanyltransferase beta is an enzyme that in humans is encoded by the GMPPB gene.^[4]

This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. The gene encodes two transcript variants.^[4]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070284 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: GMPPB GDP-mannose pyrophosphorylase B".

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ono T, Sekino-Suzuki N, Kikkawa Y, et al. (2003). "Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons". J. Neurosci. 23 (13): 5887–96. doi:10.1523/JNEUROSCI.23-13-05887.2003. PMC 6741272. PMID 12843293.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
Ning B, Elbein AD (2001). "Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins". Eur. J. Biochem. 267 (23): 6866–74. doi:10.1046/j.1432-1033.2000.01781.x. PMID 11082198.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000070284 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: GMPPB GDP-mannose pyrophosphorylase B".

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References

Further reading