MYLIP

MYLIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YHN, 2YHO
Identifiers
Aliases	MYLIP, IDOL, MIR, myosin regulatory light chain interacting protein
External IDs	OMIM: 610082; MGI: 2388271; HomoloGene: 8309; GeneCards: MYLIP; OMA:MYLIP - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	16,148,248 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	45,565,498 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; nipple; ; lower lobe of lung; ; lactiferous duct; ; synovial joint; ; renal medulla; ; saphenous vein; ; urethra; ; cardia;
	Top expressed in
	calvaria; ; lymph node; ; transitional epithelium of urinary bladder; ; ciliary body; ; tibiofemoral joint; ; parotid gland; ; sciatic nerve; ; mesenteric lymph nodes; ; skin of external ear; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; cytoskeletal protein binding; protein binding; ubiquitin-protein transferase activity; structural constituent of cytoskeleton; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; membrane; plasma membrane; intracellular anatomical structure; cytosol; cytoskeleton;
Biological process	positive regulation of protein catabolic process; negative regulation of low-density lipoprotein particle clearance; regulation of low-density lipoprotein particle receptor catabolic process; nervous system development; protein destabilization; protein ubiquitination; cholesterol homeostasis; protein polyubiquitination; actomyosin structure organization; low-density lipoprotein particle receptor catabolic process; negative regulation of neuron projection development; ubiquitin-dependent protein catabolic process; cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	29116
	218203
	ENSG00000007944
	ENSMUSG00000038175
	Q8WY64
	Q8BM54
	NM_013262
	NM_153789
	NP_037394
	NP_722484
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.^[5]

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation.^[6]^[7] The expression of IDOL is induced by the sterol-activated liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.^[8] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.

Function

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007944 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038175 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MYLIP myosin regulatory light chain interacting protein".
^ Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science. 325 (5936): 100–4. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913.
^ Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMID 19688294.
^ Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023.

Function

References

Further reading