MYLIP: Difference between revisions

MYLIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YHN, 2YHO
Identifiers
Aliases	MYLIP, IDOL, MIR, myosin regulatory light chain interacting protein
External IDs	OMIM: 610082; MGI: 2388271; HomoloGene: 8309; GeneCards: MYLIP; OMA:MYLIP - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	16,148,248 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	45,565,498 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; nipple; ; lower lobe of lung; ; lactiferous duct; ; synovial joint; ; renal medulla; ; saphenous vein; ; urethra; ; cardia;
	Top expressed in
	calvaria; ; lymph node; ; transitional epithelium of urinary bladder; ; ciliary body; ; tibiofemoral joint; ; parotid gland; ; sciatic nerve; ; mesenteric lymph nodes; ; skin of external ear; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; cytoskeletal protein binding; protein binding; ubiquitin-protein transferase activity; structural constituent of cytoskeleton; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; membrane; plasma membrane; intracellular anatomical structure; cytosol; cytoskeleton;
Biological process	positive regulation of protein catabolic process; negative regulation of low-density lipoprotein particle clearance; regulation of low-density lipoprotein particle receptor catabolic process; nervous system development; protein destabilization; protein ubiquitination; cholesterol homeostasis; protein polyubiquitination; actomyosin structure organization; low-density lipoprotein particle receptor catabolic process; negative regulation of neuron projection development; ubiquitin-dependent protein catabolic process; cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	29116
	218203
	ENSG00000007944
	ENSMUSG00000038175
	Q8WY64
	Q8BM54
	NM_013262
	NM_153789
	NP_037394
	NP_722484
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 06:10, 27 May 2024

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.^[5]

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation or MIR "Modulator Of Immune Recognition".^[6]^[7] The expression of IDOL is induced by the sterol-activated liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.^[8] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.

Function

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007944 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038175 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MYLIP myosin regulatory light chain interacting protein".
^ Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science. 325 (5936): 100–4. Bibcode:2009Sci...325..100Z. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913.
^ Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMC 11115883. PMID 19688294. S2CID 34153384.
^ Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin. Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023. PMID 19833835.

Olsson PA, Korhonen L, Mercer EA, Lindholm D (2000). "MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth". J. Biol. Chem. 274 (51): 36288–92. doi:10.1074/jbc.274.51.36288. PMID 10593918.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Olsson PA, Bornhauser BC, Korhonen L, Lindholm D (2001). "Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6". Biochem. Biophys. Res. Commun. 279 (3): 879–83. doi:10.1006/bbrc.2000.4028. PMID 11162443.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bornhauser BC, Olsson PA, Lindholm D (2003). "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain". J. Biol. Chem. 278 (37): 35412–20. doi:10.1074/jbc.M306271200. PMID 12826659.
Bornhauser BC, Johansson C, Lindholm D (2003). "Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR". FEBS Lett. 553 (1–2): 195–9. doi:10.1016/S0014-5793(03)01010-X. PMID 14550572. S2CID 25599548.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ohmura-Hoshino M, Matsuki Y, Aoki M, et al. (2006). "Inhibition of MHC class II expression and immune responses by c-MIR". J. Immunol. 177 (1): 341–54. doi:10.4049/jimmunol.177.1.341. PMID 16785530.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007944 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038175 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MYLIP myosin regulatory light chain interacting protein".

[pmid19520913-6] Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science. 325 (5936): 100–4. Bibcode:2009Sci...325..100Z. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913.

[pmid19688294-7] Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMC 11115883. PMID 19688294. S2CID 34153384.

[8] Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin. Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023. PMID 19833835.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Myosin regulatory light chain interacting protein''', also known as '''MYLIP''', is a [[protein]] that in humans is encoded by the ''MYLIP'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYLIP myosin regulatory light chain interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29116}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation or MIR "Modulator Of Immune Recognition".<ref name="pmid19520913">{{cite journal |vauthors=Zelcer N, Hong C, Boyadjian R, Tontonoz P | title = LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor | journal = Science | volume = 325 | issue = 5936 | pages = 100–4 |date=July 2009 | pmid = 19520913 | doi = 10.1126/science.1168974 | pmc = 2777523 | bibcode = 2009Sci...325..100Z }}</ref><ref name="pmid19688294">{{cite journal |vauthors=Lindholm D, Bornhauser BC, Korhonen L | title = Mylip makes an Idol turn into regulation of LDL receptor | journal = Cell. Mol. Life Sci. | volume = 66 | issue = 21 | pages = 3399–402 |date=November 2009 | pmid = 19688294 | doi = 10.1007/s00018-009-0127-y | s2cid = 34153384 | pmc = 11115883 }}</ref>  The expression of IDOL is induced by the sterol-activated [[liver X receptor]].
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Myosin regulatory light chain interacting protein
- | HGNCid = 21155
- | Symbol = MYLIP
- | AltSymbols =; MIR
- | OMIM = 610082
- | ECnumber =
- | Homologene = 8309
- | MGIid = 2388271
- | GeneAtlas_image1 = PBB_GE_MYLIP_220319_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0008092 |text = cytoskeletal protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 29116
-    | Hs_Ensembl = ENSG00000007944
-    | Hs_RefseqProtein = NP_037394
-    | Hs_RefseqmRNA = NM_013262
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 16237296
-    | Hs_GenLoc_end = 16256455
-    | Hs_Uniprot = Q8WY64
-    | Mm_EntrezGene = 218203
-    | Mm_Ensembl = ENSMUSG00000038175
-    | Mm_RefseqmRNA = XM_978411
-    | Mm_RefseqProtein = XP_983505
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 13
-    | Mm_GenLoc_start = 45400714
-    | Mm_GenLoc_end = 45422912
-    | Mm_Uniprot = Q3TAE7
-  }}
-}}
-'''Myosin regulatory light chain interacting protein''', also known as '''MYLIP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYLIP myosin regulatory light chain interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29116| accessdate = }}</ref>
+'''Increased Degradation of LDL Receptor Protein''' (IDOL) is a [[ubiquitin]] ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.<ref>{{cite journal | author = Sawamura, T. | title = New Idol for cholesterol reduction? | journal = Clin. Chem. | volume = 55 | issue = 12| pages = 2082–2084 |date= 2009 | pmid = 19833835| doi = 10.1373/clinchem.2009.134023 | doi-access = free }}</ref> Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
+== Function ==
-| section_title =
-| summary_text = The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.<ref name="entrez">{{cite web | title = Entrez Gene: MYLIP myosin regulatory light chain interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29116| accessdate = }}</ref>
+The [[ERM protein family]] members [[ezrin]], [[radixin]], and [[moesin]] are [[cytoskeleton|cytoskeletal]] effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits [[neurite]] outgrowth.<ref name="entrez"/>
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  |vauthors=Olsson PA, Korhonen L, Mercer EA, Lindholm D |title=MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36288–92 |year= 2000 |pmid= 10593918 |doi=10.1074/jbc.274.51.36288  |doi-access=free }}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934  }}
-| citations =
-*{{cite journal  | author=Olsson PA, Korhonen L, Mercer EA, Lindholm D |title=MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36288–92 |year= 2000 |pmid= 10593918 |doi=  }}
+*{{cite journal  |vauthors=Olsson PA, Bornhauser BC, Korhonen L, Lindholm D |title=Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 879–83 |year= 2001 |pmid= 11162443 |doi= 10.1006/bbrc.2000.4028 }}
-*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Olsson PA, Bornhauser BC, Korhonen L, Lindholm D |title=Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 879–83 |year= 2001 |pmid= 11162443 |doi= 10.1006/bbrc.2000.4028 }}
+*{{cite journal  |vauthors=Bornhauser BC, Olsson PA, Lindholm D |title=MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35412–20 |year= 2003 |pmid= 12826659 |doi= 10.1074/jbc.M306271200 |doi-access= free }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Bornhauser BC, Johansson C, Lindholm D |title=Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. |journal=FEBS Lett. |volume=553 |issue= 1–2 |pages= 195–9 |year= 2003 |pmid= 14550572 |doi=10.1016/S0014-5793(03)01010-X  |s2cid=25599548 |doi-access=free }}
-*{{cite journal  | author=Bornhauser BC, Olsson PA, Lindholm D |title=MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35412–20 |year= 2003 |pmid= 12826659 |doi= 10.1074/jbc.M306271200 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Bornhauser BC, Johansson C, Lindholm D |title=Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. |journal=FEBS Lett. |volume=553 |issue= 1-2 |pages= 195–9 |year= 2003 |pmid= 14550572 |doi=  }}
+*{{cite journal   |vauthors=Wan D, Gong Y, Qin W, etal |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101  | pmc=524842 |bibcode=2004PNAS..10115724W |doi-access=free }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
-*{{cite journal  | author=Wan D, Gong Y, Qin W, ''et al.'' |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 }}
+*{{cite journal   |vauthors=Ohmura-Hoshino M, Matsuki Y, Aoki M, etal |title=Inhibition of MHC class II expression and immune responses by c-MIR. |journal=J. Immunol. |volume=177 |issue= 1 |pages= 341–54 |year= 2006 |pmid= 16785530 |doi=  10.4049/jimmunol.177.1.341|doi-access=free }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Ohmura-Hoshino M, Matsuki Y, Aoki M, ''et al.'' |title=Inhibition of MHC class II expression and immune responses by c-MIR. |journal=J. Immunol. |volume=177 |issue= 1 |pages= 341–54 |year= 2006 |pmid= 16785530 |doi=  }}
-}}
 {{refend}}
-{{gene-6-stub}}
+{{Cytoskeletal proteins}}{{gene-6-stub}}