Talk:Human Physiology/Blood physiology

I found some more images for you to use in your chapter.

And there are more images for use in the following category:

• commons:Category:Blood cells

Let me know if you need anything else. --Whiteknight (talk) (projects) 23:57, 7 August 2006 (UTC) Thank you so much for the pictures! We really need them, your a great help! Thank you!--Jacquel 02:08, 9 August 2006 (UTC)Reply

Just glancing through the chapter, the one thing that first stood out as missing is a description of blood clotting (platelet plug; clotting cascade). The section on disorders is pretty long--especially (I thought) the section on sickle cell disease. It is easy to get a lot of information on disorders, but we need to stick to the physiology of what is causing the disorders. Also, it is worth considering what disorders to include. There could be more ties made between the blood and other systems. Blood volume, for example, is largely regulated by the kidneys. Actually, the kidneys are heavily involved in potassium ion levels and other ions in the blood as well as regulating pH. I think in class I will talk quite a bit on the mechanism of blood clotting, as well as bring up bleeding disorders (well, hemophilia at least) and anticoagulants and their clinical use. Other thoughts for possible things to include: a discussion of hypertension, flow of blood in the capillaries and how exchange takes place with interstitial fluids, and hypovolemic shock (maybe some of these topics are in the chapter on cardiovascular system). Provophys 23:20, 12 March 2007 (UTC)Reply

Thanks for the ideas on what could be changed this helped me alot to know where to get started. Do we need to have all of those references and external links or can they be removed also?

I dont know what happened when I saved the pg it was really horizontal. Please fix I dont know how. Please feel free to add to my brief discussion on blood clotting I have only just begun.

7-5-2011 In the description of RBCs it first says there are 250 million hemoglobin (molecules)- then later it says there are around 200 million. It only needs to say one or the other.

I took the liberty to cut this portion out of the section on blood clotting. If anyone is feeling attached to it, I don't mind if you put it back in. I tried to make this section more clear. Hope it is. I still haven't figured out how to talk about the "extrinsic pathway". Any ideas?

"Coagulation is initiated within 20 seconds after the injury. Platelets immediately form a hemostatic plug at the site of injury. This is called primary hemostasis. Platelets are activated by thrombin and aggregate at the site of injury, forming a temporary plug. The protein fibrinogen is primarily responsible for stimulating platelet clumping. Platelets clump by binding to collagen that becomes exposed following the injury. Upon instigation, platelets release nucleotide, ADP and the eicosanoid, TXA2 (both of which activate additional platelets), serotonin, phospholipids, lipoproteins, and other proteins that are important for coagulation. Platelets then change their shape to the formation of the plug. To make sure the clot is strong enough to ensure no more blood loss, fibrinogen is converted into fibrin. This makes a strong barrier over the blood platelets. This forms a permanent blood clot until vessels and tissue have completed the repair.

Secondary hemostasis then follows; Blood plasma components called coagulation factors respond (in a complex cascade) to form fibrin strands which strengthen the platelet plug."

Well, that's all for now! never2late 05:45, 15 March 2007 (UTC)Reply

Excellent article that I find helpful in which to refer my high school and college students. I have found two statements that are confusing or in error. The first is the last sentence in the Plasma makeup section. Carbon dioxide has 3 forms in the blood: 10% dissolved, 70% in the form of bicarbonate, and 20% bound to hemoglobin. Oxygen has 2 forms: 3% dissolved and 97% bound to hemoglobin. I don't understand where you get that 97% of CO2 is carried by the plasma. By my thinking I would exclude that bound to hgb as you did with O2 and also exclude what is in the form of bicarb to end up with 10% rather than 97%.

Also, in the Platelets section, you wrote, "are about 1/10th to 1/20th as abundant as white blood cells." A normal WBC count is 4,500 to 10,000 cells/mcL whereas a normal platelet count is 150,000 to 450,000 cells/mcL. So I think you meant the reverse, that platelets are 10 to 20 times more abundant than white blood cells.

Thanks! --Kris (discuss • contribs) 18:38, 28 December 2011 (UTC)Reply

Or perhaps you meant that platelets are 1/10 to 120th as abundant as RED blood cells. --Kris (discuss • contribs) 00:01, 30 December 2011 (UTC)Reply