UBA5

UBA5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3GUC, 3H8V, 5HKH
Dynodwyr
Cyfenwau	UBA5, THIFP1, UBE1DC1, ubiquitin like modifier activating enzyme 5, SCAR24, EIEE44, DEE44
Dynodwyr allanol	OMIM: 610552 HomoloGene: 11738 GeneCards: UBA5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0001948, GO:0016582 protein binding • ubiquitin-like modifier activating enzyme activity • ATP binding • metal ion binding • UFM1 activating enzyme activity Cydrannau o'r gell • cytoplasm • intracellular membrane-bounded organelle • cnewyllyn cell • cytosol • Golgi apparatus Prosesau biolegol • regulation of intracellular estrogen receptor signaling pathway • protein K69-linked ufmylation • response to endoplasmic reticulum stress • protein ufmylation • neuromuscular process • protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	79876	n/a
Ensembl	ENSG00000081307	n/a
UniProt	Q9GZZ9	n/a
RefSeq (mRNA)	NM_024818 NM_198329 NM_001320210 NM_001321238 NM_001321239	n/a
RefSeq (protein)	NP_001307139 NP_001308167 NP_001308168 NP_079094 NP_938143	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBA5 yw UBA5 a elwir hefyd yn Ubiquitin-like modifier-activating enzyme 5 ac Ubiquitin like modifier activating enzyme 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q22.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBA5.

• "UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins. ". J Cell Biochem. 2008. PMID 18442052.
• "Isolation and characterization of ubiquitin-activating enzyme E1-domain containing 1, UBE1DC1. ". Mol Biol Rep. 2005. PMID 16328888.
• "Compound heterozygous mutations in UBA5 causing early-onset epileptic encephalopathy in two sisters. ". BMC Med Genet. 2017. PMID 28965491.
• "Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. ". J Biol Chem. 2016. PMID 26929408.
• "Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.". J Biol Chem. 2010. PMID 20368332.