WRN

WRN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AXL, 2DGZ, 2E1E, 2E1F, 2FBT, 2FBV, 2FBX, 2FBY, 2FC0, 3AAF
Dynodwyr
Cyfenwau	WRN, RECQ3, RECQL2, RECQL3, Werner syndrome RecQ like helicase, WRN RecQ like helicase
Dynodwyr allanol	OMIM: 604611 HomoloGene: 6659 GeneCards: WRN
EC number	3.1.-.-
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • nucleotide binding • manganese ion binding • protein homodimerization activity • GO:0008026 helicase activity • GO:0004003 DNA helicase activity • bubble DNA binding • chromatin binding • metal ion binding • G-quadruplex DNA binding • ATPase activity • GO:0001948, GO:0016582 protein binding • catalytic activity • 3'-5' exonuclease activity • Y-form DNA binding • nucleic acid binding • nuclease activity • GO:0043140 3'-5' DNA helicase activity • GO:1990163 four-way junction helicase activity • ATP binding • magnesium ion binding • hydrolase activity • exonuclease activity • telomeric D-loop binding • 3'-flap-structured DNA binding • four-way junction DNA binding • forked DNA-dependent helicase activity • telomeric G-quadruplex DNA binding • 8-hydroxy-2'-deoxyguanosine DNA binding • GO:0032403 protein-containing complex binding • MutLalpha complex binding Cydrannau o'r gell • centrosome • intracellular anatomical structure • nucleoplasm • nucleolus • neuron projection • MutLalpha complex • cnewyllyn cell • cytoplasm • nuclear speck • telomere • replication fork • DNA replication factor A complex • Cromosom • site of double-strand break Prosesau biolegol • regulation of apoptotic process • positive regulation of hydrolase activity • DNA recombination • cellular response to starvation • DNA metabolic process • GO:0010260 heneiddio • GO:0001306 response to oxidative stress • cellular response to DNA damage stimulus • regulation of growth rate • brain development • metaboledd celloedd • cellular response to gamma radiation • replication fork processing • multicellular organism aging • metabolaeth • nucleobase-containing compound metabolic process • response to UV-C • base-excision repair • double-strand break repair • GO:0100026 DNA repair • nucleic acid phosphodiester bond hydrolysis • double-strand break repair via homologous recombination • DNA duplex unwinding • DNA replication • telomeric D-loop disassembly • t-circle formation • positive regulation of strand invasion • telomere maintenance • G-quadruplex DNA unwinding • protein localization to nucleolus • DNA synthesis involved in DNA repair • determination of adult lifespan • regulation of signal transduction by p53 class mediator • DNA unwinding involved in DNA replication Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7486	n/a
Ensembl	ENSG00000165392	n/a
UniProt	Q14191	n/a
RefSeq (mRNA)	NM_000553	n/a
RefSeq (protein)	NP_000544	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn WRN yw WRN a elwir hefyd yn Werner syndrome RecQ like helicase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p12.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WRN.

• RECQ3
• RECQL2
• RECQL3

• "Localization of the Werner Protein Together with H2AX in γ-Irradiation-Induced Neoplastic Transformed Human Mesenchymal Stem Cells. ". Crit Rev Eukaryot Gene Expr. 2017. PMID 28436335.
• "Recent Trends in WRN Gene Mutation Patterns in Individuals with Werner Syndrome. ". J Am Geriatr Soc. 2017. PMID 28394436.
• "Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA. ". J Biol Chem. 2017. PMID 28069813.
• "Genetic variation in WRN and ischemic stroke: General population studies and meta-analyses. ". Exp Gerontol. 2017. PMID 28063943.
• "WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells.". J Hematol Oncol. 2016. PMID 27829440.