RGS2

RGS2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AF0, 2V4Z, 4EKC, 4EKD
Dynodwyr
Cyfenwau	RGS2, G0S8, regulator of G-protein signaling 2, regulator of G protein signaling 2
Dynodwyr allanol	OMIM: 600861 HomoloGene: 2192 GeneCards: RGS2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • calmodulin binding • GO:0001948, GO:0016582 protein binding • G-protein alpha-subunit binding • beta-tubulin binding • GO:0006184 GTPase activity Cydrannau o'r gell • bilen • nucleolus • mitocondria • neuron projection • cytoplasmic side of plasma membrane • cnewyllyn cell • cytoplasm • Cellbilen • cytosol Prosesau biolegol • negative regulation of cAMP-mediated signaling • regulation of G protein-coupled receptor signaling pathway • negative regulation of cardiac muscle hypertrophy • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of MAP kinase activity • positive regulation of cardiac muscle contraction • spermatogenesis • brown fat cell differentiation • positive regulation of microtubule polymerization • relaxation of vascular associated smooth muscle • cell cycle • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • relaxation of cardiac muscle • regulation of translation • negative regulation of phospholipase activity • negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process • response to amphetamine • brain development • positive regulation of neuron projection development • negative regulation of translation • ovulation • response to ethanol • maternal process involved in female pregnancy • negative regulation of cell growth involved in cardiac muscle cell development • negative regulation of glycine import across plasma membrane • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5997	n/a
Ensembl	ENSG00000116741	n/a
UniProt	P41220	n/a
RefSeq (mRNA)	NM_002923	n/a
RefSeq (protein)	NP_002914 NP_002914.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RGS2 yw RGS2 a elwir hefyd yn Regulator of G protein signaling 2 a Regulator of G-protein signalling 2, 24kDa, isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q31.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RGS2.

• G0S8

• "The RGS2 (-391, C>G) genetic variation correlates to antihypertensive drug responses in Chinese patients with essential hypertension. ". PLoS One. 2015. PMID 25849301.
• "RGS2 ggenetic variation: association analysis with panic disorder and dimensional as well as intermediate phenotypes of anxiety. ". Am J Med Genet B Neuropsychiatr Genet. 2015. PMID 25740197.
• "Human Missense Mutations in Regulator of G Protein Signaling 2 Affect the Protein Function Through Multiple Mechanisms. ". Mol Pharmacol. 2017. PMID 28784619.
• "RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer's disease: genome-wide transcriptomic profiling and bioinformatics data mining. ". Transl Psychiatry. 2016. PMID 27701409.
• "An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women.". BMC Genet. 2016. PMID 27558088.