RAC1

RAC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E96, 1FOE, 1G4U, 1HE1, 1HH4, 1I4D, 1I4L, 1I4T, 1MH1, 1RYF, 1RYH, 2FJU, 2H7V, 2NZ8, 2P2L, 2RMK, 2VRW, 2WKP, 2WKQ, 2WKR, 2YIN, 3B13, 3BJI, 3RYT, 3SBD, 3SBE, 3SU8, 3SUA, 3TH5, 4GZL, 4GZM, 4YON, 5FI0
Dynodwyr
Cyfenwau	RAC1, MIG5, Rac-1, TC-25, p21-Rac1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), Rac family small GTPase 1, MRD48
Dynodwyr allanol	OMIM: 602048 HomoloGene: 69035 GeneCards: RAC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • histone deacetylase binding • Rho GDP-dissociation inhibitor binding • GTP-dependent protein binding • GO:0006184 GTPase activity • enzyme binding • GO:0001948, GO:0016582 protein binding • thioesterase binding • protein kinase binding • nucleotide binding • GTP binding • protein serine/threonine kinase activity • GO:0032403 protein-containing complex binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • ATPase binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • focal adhesion • melanosome • ruffle membrane • trans-Golgi network • cnewyllyn cell • cell projection • extrinsic component of plasma membrane • extracellular exosome • lamellipodium • early endosome membrane • Cellbilen • Microffilament • cytoplasmic ribonucleoprotein granule • endoplasmic reticulum membrane • Golgi membrane • phagocytic cup • GO:0016023 cytoplasmic vesicle • GO:0005578 extracellular matrix • secretory granule membrane • dendritic spine • recycling endosome membrane • postsynapse • glutamatergic synapse • ficolin-1-rich granule membrane Prosesau biolegol • positive regulation of Rho protein signal transduction • regulation of respiratory burst • non-canonical Wnt signaling pathway • positive regulation of protein phosphorylation • positive regulation of actin filament polymerization • regulation of neuron maturation • negative regulation of receptor-mediated endocytosis • platelet activation • Fc-epsilon receptor signaling pathway • cellular response to mechanical stimulus • phagocytosis, engulfment • vascular endothelial growth factor receptor signaling pathway • substrate adhesion-dependent cell spreading • cell population proliferation • ruffle assembly • lamellipodium assembly • dopaminergic neuron differentiation • cell-cell junction organization • Fc-gamma receptor signaling pathway involved in phagocytosis • ruffle organization • actin filament organization • cell motility • anatomical structure morphogenesis • bone resorption • response to wounding • protein localization to plasma membrane • inflammatory response • regulation of small GTPase mediated signal transduction • positive regulation of cell-substrate adhesion • G protein-coupled receptor signaling pathway • neuron projection morphogenesis • epithelial cell morphogenesis • dendrite morphogenesis • regulation of hydrogen peroxide metabolic process • engulfment of apoptotic cell • dendrite development • auditory receptor cell morphogenesis • hyperosmotic response • cerebral cortex GABAergic interneuron development • chemotaxis • positive regulation of DNA replication • actin filament polymerization • cell adhesion • negative regulation of interleukin-23 production • homeostasis of number of cells within a tissue • cell-matrix adhesion • localization within membrane • actin cytoskeleton organization • regulation of cell size • anatomical structure arrangement • GO:0007243 intracellular signal transduction • regulation of cell migration • endocytosis • ephrin receptor signaling pathway • T cell costimulation • blood coagulation • GO:0019049, GO:0030683 mitigation of host defenses by virus • synaptic transmission, GABAergic • mast cell chemotaxis • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of substrate adhesion-dependent cell spreading • embryonic olfactory bulb interneuron precursor migration • cytoskeleton organization • cochlea morphogenesis • positive regulation of neutrophil chemotaxis • positive regulation of apoptotic process • regulation of cell morphogenesis • positive regulation of focal adhesion assembly • regulation of fibroblast migration • positive regulation of lamellipodium assembly • cerebral cortex radially oriented cell migration • cell migration • semaphorin-plexin signaling pathway • positive regulation of stress fiber assembly • axon guidance • small GTPase mediated signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • Wnt signaling pathway, planar cell polarity pathway • midbrain dopaminergic neuron differentiation • neuron migration • protein phosphorylation • Rho protein signal transduction • regulation of lamellipodium assembly • Rac protein signal transduction • cell projection assembly • positive regulation of microtubule polymerization • neutrophil degranulation • regulation of nitric oxide biosynthetic process • phosphatidylinositol phosphate biosynthetic process • hepatocyte growth factor receptor signaling pathway • regulation of stress fiber assembly • positive regulation of protein kinase B signaling • motor neuron axon guidance • regulation of neutrophil migration • positive regulation of insulin secretion involved in cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5879	n/a
Ensembl	ENSG00000136238	n/a
UniProt	P63000	n/a
RefSeq (mRNA)	NM_198829 NM_006908 NM_018890	n/a
RefSeq (protein)	NP_008839 NP_061485	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAC1 yw RAC1 a elwir hefyd yn Rac family small GTPase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7p22.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAC1.

• "High expression of Rac1 is correlated with partial reversed cell polarity and poor prognosis in invasive ductal carcinoma of the breast. ". Tumour Biol. 2017. PMID 28671041.
• "Emerging roles of RAC1 in treating lung cancer patients. ". Clin Genet. 2017. PMID 27790713.
• "Impact of point mutation P29S in RAC1 on tumorigenesis. ". Tumour Biol. 2016. PMID 27699663.
• "Rac-ing from Epithelial Secretor to Eater. ". Dev Cell. 2016. PMID 27623380.
• "Growth arrest of lung carcinoma cells (A549) by polyacrylate-anchored peroxovanadate by activating Rac1-NADPH oxidase signalling axis.". Mol Cell Biochem. 2016. PMID 27435854.