RNF8

RNF8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CSW, 2PIE, 4AYC, 4ORH, 4WHV
Dynodwyr
Cyfenwau	RNF8, hring finger protein 8
Dynodwyr allanol	OMIM: 611685 HomoloGene: 2944 GeneCards: RNF8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • GO:0031493 histone binding • chromatin binding • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • transferase activity • identical protein binding • zinc ion binding • ubiquitin binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cydrannau o'r gell • site of double-strand break • ubiquitin ligase complex • nucleoplasm • Cromosom • telomere • midbody • cnewyllyn cell • cytosol • cytoplasm Prosesau biolegol • response to ionizing radiation • histone H2A ubiquitination • interstrand cross-link repair • ubiquitin-dependent protein catabolic process • protein K63-linked ubiquitination • GO:1900404 positive regulation of DNA repair • histone H2A K63-linked ubiquitination • negative regulation of transcription elongation from RNA polymerase II promoter • cellular response to DNA damage stimulus • Cellraniad • protein K48-linked ubiquitination • isotype switching • protein ubiquitination • spermatid development • cell cycle • histone H2B ubiquitination • double-strand break repair via nonhomologous end joining • GO:0035042 histone exchange • protein autoubiquitination • double-strand break repair • GO:0100026 DNA repair • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9025	n/a
Ensembl	ENSG00000112130	n/a
UniProt	O76064	n/a
RefSeq (mRNA)	NM_003958 NM_183078	n/a
RefSeq (protein)	NP_003949 NP_898901	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RNF8 yw RNF8 a elwir hefyd yn Ring finger protein 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RNF8.

• hRNF8

• "Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy. ". Oncotarget. 2016. PMID 26788910.
• "RNF8 plays an important role in the radioresistance of human nasopharyngeal cancer cells in vitro. ". Oncol Rep. 2015. PMID 25955491.
• "RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. ". J Exp Med. 2017. PMID 28507061.
• "RNF8 negatively regulates NF-kappaB signaling by targeting IkappaB kinase: implications for the regulation of inflammation signaling. ". Biochem Biophys Res Commun. 2017. PMID 28499869.
• "RNF8 promotes epithelial-mesenchymal transition of breast cancer cells.". J Exp Clin Cancer Res. 2016. PMID 27259701.