PTPRJ

PTPRJ
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CFV, 2DLE, 2NZ6
Dynodwyr
Cyfenwau	PTPRJ, CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, protein tyrosine phosphatase, receptor type J, protein tyrosine phosphatase receptor type J, R-PTP-J, HPTP eta
Dynodwyr allanol	OMIM: 600925 HomoloGene: 2130 GeneCards: PTPRJ
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • beta-catenin binding • phosphoprotein phosphatase activity • gamma-catenin binding • GO:0098519, GO:0098518 phosphatase activity • delta-catenin binding • mitogen-activated protein kinase binding • platelet-derived growth factor receptor binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • protein kinase binding • protein tyrosine phosphatase activity Cydrannau o'r gell • integral component of membrane • cell projection • bilen • cell-cell junction • Cellbilen • integral component of plasma membrane • ruffle membrane • cell surface • cell junction • immunological synapse • extracellular exosome • specific granule membrane Prosesau biolegol • negative regulation of platelet-derived growth factor receptor signaling pathway • negative regulation of protein kinase B signaling • positive regulation of protein kinase B signaling • negative regulation of epidermal growth factor receptor signaling pathway • GO:0016576 protein dephosphorylation • contact inhibition • negative regulation of T cell receptor signaling pathway • regulation of cell adhesion • negative regulation of cell migration • negative regulation of MAP kinase activity • negative regulation of cell growth • positive regulation of focal adhesion assembly • platelet-derived growth factor receptor signaling pathway • positive chemotaxis • peptidyl-tyrosine dephosphorylation • T cell receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of vascular permeability • positive regulation of cell adhesion • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • neutrophil degranulation • B cell differentiation • positive regulation of tumor necrosis factor production • calcium-mediated signaling using intracellular calcium source • positive regulation of MAPK cascade • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5795	n/a
Ensembl	ENSG00000149177	n/a
UniProt	Q12913	n/a
RefSeq (mRNA)	NM_001098503 NM_002843	n/a
RefSeq (protein)	NP_001091973 NP_002834	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPRJ yw PTPRJ a elwir hefyd yn Receptor-type tyrosine-protein phosphatase eta a Protein tyrosine phosphatase, receptor type J (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p11.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPRJ.

• "Blockage of PTPRJ promotes cell growth and resistance to 5-FU through activation of JAK1/STAT3 in the cervical carcinoma cell line C33A. ". Oncol Rep. 2015. PMID 25634668.
• "Phosphorylation of DEP-1/PTPRJ on threonine 1318 regulates Src activation and endothelial cell permeability induced by vascular endothelial growth factor. ". Cell Signal. 2014. PMID 24583284.
• "Loss of Protein Tyrosine Phosphatase Receptor J Expression Predicts an Aggressive Clinical Course in Patients with Esophageal Squamous Cell Carcinoma. ". Pathol Oncol Res. 2016. PMID 26694178.
• "The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis. ". Oncogene. 2015. PMID 25772245.
• "Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells.". J Neurooncol. 2015. PMID 25672645.