PTP4A3

PTP4A3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1R6H, 1V3A, 2MBC
Dynodwyr
Cyfenwau	PTP4A3, PRL-3, PRL-R, PRL3, protein tyrosine phosphatase type IVA, member 3, protein tyrosine phosphatase 4A3
Dynodwyr allanol	OMIM: 606449 HomoloGene: 22500 GeneCards: PTP4A3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein tyrosine phosphatase activity • prenylated protein tyrosine phosphatase activity • GO:0098519, GO:0098518 phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • endosome • Cellbilen • early endosome • bilen • cnewyllyn cell • cytoplasm Prosesau biolegol • Notch signaling pathway • GO:0016576 protein dephosphorylation • positive regulation of vascular permeability • regulation of vascular endothelial growth factor signaling pathway • endothelial cell migration • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • peptidyl-tyrosine dephosphorylation • GO:0009373 regulation of transcription, DNA-templated • positive regulation of NIK/NF-kappaB signaling • positive regulation of establishment of protein localization • cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11156	n/a
Ensembl	ENSG00000184489 ENSG00000275575	n/a
UniProt	O75365	n/a
RefSeq (mRNA)	NM_007079 NM_032611	n/a
RefSeq (protein)	NP_009010 NP_116000	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTP4A3 yw PTP4A3 a elwir hefyd yn Protein tyrosine phosphatase type IVA, member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8q24.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTP4A3.

• PRL3
• PRL-3
• PRL-R

• "Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia. ". Leuk Res. 2017. PMID 28063378.
• "Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3. ". Biochem Soc Trans. 2016. PMID 27911713.
• "Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer. ". PLoS One. 2017. PMID 29190795.
• "PRL-3 promotes telomere deprotection and chromosomal instability. ". Nucleic Acids Res. 2017. PMID 28482095.
• "Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion.". PLoS One. 2017. PMID 28068414.