PRKCH

PRKCH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2FK9, 3TXO
Dynodwyr
Cyfenwau	PRKCH, PKC-L, PKCL, PRKCL, nPKC-eta, protein kinase C eta
Dynodwyr allanol	OMIM: 605437 HomoloGene: 84384 GeneCards: PRKCH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • protein kinase C activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • calcium-independent protein kinase C activity • enzyme binding • ATP binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • cell-cell junction • Cellbilen • extracellular exosome • intracellular anatomical structure Prosesau biolegol • positive regulation of B cell receptor signaling pathway • cell differentiation • GO:0007243 intracellular signal transduction • phosphorylation • regulation of bicellular tight junction assembly • positive regulation of keratinocyte differentiation • negative regulation of glial cell apoptotic process • protein kinase C signaling • platelet activation • protein phosphorylation • positive regulation of macrophage derived foam cell differentiation • positive regulation of NF-kappaB transcription factor activity • GO:0035404 peptidyl-serine phosphorylation • positive regulation of glial cell proliferation • GO:0072468 signal transduction • positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5583	n/a
Ensembl	ENSG00000027075	n/a
UniProt	P24723	n/a
RefSeq (mRNA)	NM_006255	n/a
RefSeq (protein)	NP_006246	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKCH yw PRKCH a elwir hefyd yn Protein kinase C eta type a Protein kinase C eta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKCH.

• "A quantitative assessment of the association between 1425G/A polymorphism in PRKCH and risk of stroke. ". Neuromolecular Med. 2014. PMID 25272991.
• "Silencing of PKCη induces cycle arrest of EBV(+) B lymphoma cells by upregulating expression of p38-MAPK/TAp73/GADD45α and increases susceptibility to chemotherapeutic agents. ". Cancer Lett. 2014. PMID 24784886.
• "PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia. ". Exp Hematol. 2017. PMID 28596089.
• "Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population. ". Biomed J. 2015. PMID 25900926.
• "PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population.". Mol Neurobiol. 2015. PMID 25370935.