SHC1

SHC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MIL, 1N3H, 1OY2, 1QG1, 1SHC, 1TCE, 2L1C, 4JMH, 4XWX, 5CZI
Dynodwyr
Cyfenwau	SHC1, SHC, SHCA, SHC adaptor protein 1
Dynodwyr allanol	OMIM: 600560 HomoloGene: 7934 GeneCards: SHC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • insulin-like growth factor receptor binding • transmembrane receptor protein tyrosine kinase adaptor activity • insulin receptor binding • neurotrophin TRKA receptor binding • ephrin receptor binding • epidermal growth factor receptor binding • receptor tyrosine kinase binding • GO:0001948, GO:0016582 protein binding • phospholipid binding • epidermal growth factor binding • phosphotyrosine residue binding Cydrannau o'r gell • cytoplasm • cytosol • mitochondrial matrix • mitocondria • Shc-EGFR complex • Cellbilen Prosesau biolegol • actin cytoskeleton reorganization • GO:1901047 insulin receptor signaling pathway • GO:0007243 intracellular signal transduction • epidermal growth factor receptor signaling pathway • cellular response to growth factor stimulus • MAPK cascade • Fc-epsilon receptor signaling pathway • heart development • IRE1-mediated unfolded protein response • regulation of cell population proliferation • angiogenesis • regulation of epidermal growth factor-activated receptor activity • regulation of growth • Ras protein signal transduction • GO:0022415 viral process • leukocyte migration • GO:0072468 signal transduction • ERBB2 signaling pathway • axon guidance • defense response to bacterium • negative regulation of apoptotic process • positive regulation of MAPK cascade • GO:0045996 negative regulation of transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of ERK1 and ERK2 cascade • cell-cell adhesion • interleukin-15-mediated signaling pathway • negative regulation of angiogenesis • cytokine-mediated signaling pathway • interleukin-2-mediated signaling pathway • positive regulation of cell proliferation in bone marrow • regulation of superoxide metabolic process • positive regulation of cell population proliferation • positive regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6464	n/a
Ensembl	ENSG00000160691	n/a
UniProt	P29353	n/a
RefSeq (mRNA)	NM_001130040 NM_001130041 NM_001202859 NM_003029 NM_183001	n/a
RefSeq (protein)	NP_001123512 NP_001123513 NP_001189788 NP_003020 NP_892113	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SHC1 yw SHC1 a elwir hefyd yn SHC adaptor protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SHC1.

• SHC
• SHCA

• "Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene. ". Mol Biol Cell. 2014. PMID 24807908.
• "Sulfhydration of p66Shc at cysteine59 mediates the antioxidant effect of hydrogen sulfide. ". Antioxid Redox Signal. 2014. PMID 24766279.
• "Nicotine Exposure Augments Renal Toxicity of 5-aza-cytidine Through p66shc: Prevention by Resveratrol. ". Anticancer Res. 2017. PMID 28739690.
• "The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway. ". Int J Clin Exp Pathol. 2015. PMID 26464652.
• "Adaptor protein p66(Shc) mediates hypertension-associated, cyclic stretch-dependent, endothelial damage.". Hypertension. 2014. PMID 24842918.