MICAL1

MICAL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WYL, 2CO8
Dynodwyr
Cyfenwau	MICAL1, MICAL, MICAL-1, NICAL, microtubule associated monooxygenase, calponin and LIM domain containing 1
Dynodwyr allanol	OMIM: 607129 HomoloGene: 11246 GeneCards: MICAL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SH3 domain binding • oxidoreductase activity • actin binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • FAD binding • GO:0001948, GO:0016582 protein binding • metal ion binding • protein kinase binding • monooxygenase activity • NAD(P)H oxidase H2O2-forming activity • actin filament binding Cydrannau o'r gell • cytoplasm • Cytosgerbwd • intermediate filament • hippocampal mossy fiber expansion • cytosol • midbody • intercellular bridge • Cellbilen • actin cytoskeleton Prosesau biolegol • GO:0033128 negative regulation of protein phosphorylation • actin filament depolymerization • sulfur oxidation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of apoptotic process • cytoskeleton organization • GO:0072468 signal transduction • regulation of regulated secretory pathway • blood coagulation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	64780	n/a
Ensembl	n/a	n/a
UniProt	Q8TDZ2	n/a
RefSeq (mRNA)	NM_022765 NM_001159291 NM_001286613	n/a
RefSeq (protein)	NP_001152763 NP_001273542 NP_073602	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MICAL1 yw MICAL1 a elwir hefyd yn Microtubule associated monooxygenase, calponin and LIM domain containing 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q21.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MICAL1.

• MICAL
• NICAL
• MICAL-1

• "Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein. ". J Neurosci. 2008. PMID 18305261.
• "Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain. ". Biophys Chem. 2007. PMID 17662518.
• "Structure-function studies of MICAL, the unusual multidomain flavoenzyme involved in actin cytoskeleton dynamics. ". Arch Biochem Biophys. 2017. PMID 28602956.
• "MICAL-family proteins: Complex regulators of the actin cytoskeleton. ". Antioxid Redox Signal. 2014. PMID 23834433.
• "Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly.". Cytoskeleton (Hoboken). 2011. PMID 21800438.