HSP90B1

HSP90B1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4NH9
Dynodwyr
Cyfenwau	HSP90B1, ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1, heat shock protein 90kDa beta family member 1, heat shock protein 90 beta family member 1
Dynodwyr allanol	OMIM: 191175 HomoloGene: 2476 GeneCards: HSP90B1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • calcium ion binding • unfolded protein binding • low-density lipoprotein particle receptor binding • GO:0001948, GO:0016582 protein binding • RNA binding • protein phosphatase binding • ATP binding Cydrannau o'r gell • cytosol • endocytic vesicle lumen • endoplasmic reticulum lumen • endoplasmic reticulum membrane • bilen • focal adhesion • GO:0005578 extracellular matrix • melanosome • Cellbilen • endoplasmic reticulum chaperone complex • extracellular region • midbody • Reticwlwm endoplasmig • perinuclear region of cytoplasm • extracellular exosome • cnewyllyn cell • GO:0009327 protein-containing complex • collagen-containing extracellular matrix Prosesau biolegol • response to hypoxia • response to stress • protein folding in endoplasmic reticulum • negative regulation of apoptotic process • receptor-mediated endocytosis • response to endoplasmic reticulum stress • toll-like receptor signaling pathway • regulation of phosphoprotein phosphatase activity • ATF6-mediated unfolded protein response • actin rod assembly • retrograde protein transport, ER to cytosol • sequestering of calcium ion • protein folding • ubiquitin-dependent ERAD pathway • protein transport • cellular response to ATP • post-translational protein modification • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7184	n/a
Ensembl	ENSG00000166598	n/a
UniProt	P14625	n/a
RefSeq (mRNA)	NM_003299	n/a
RefSeq (protein)	NP_003290	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSP90B1 yw HSP90B1 a elwir hefyd yn Heat shock protein 90 beta family member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q23.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSP90B1.

• "Heat shock protein 90-β over-expression is associated with poor survival in stage I lung adenocarcinoma patients. ". Int J Clin Exp Pathol. 2015. PMID 26339394.
• "Chlamydia-infected cells shed Gp96 to prevent chlamydial re-infection. ". Mol Microbiol. 2015. PMID 26235316.
• "The Role of Heat Shock Protein 90B1 in Patients with Polycystic Ovary Syndrome. ". PLoS One. 2016. PMID 27046189.
• "A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production. ". Endocrinology. 2016. PMID 26982636.
• "Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.". J Biol Chem. 2016. PMID 26872972.