HNRNPA2B1

HNRNPA2B1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X4B
Dynodwyr
Cyfenwau	HNRNPA2B1, HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1, heterogeneous nuclear ribonucleoprotein A2/B1
Dynodwyr allanol	OMIM: 600124 HomoloGene: 22992 GeneCards: HNRNPA2B1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • N6-methyladenosine-containing RNA binding • pre-mRNA intronic binding • miRNA binding • single-stranded telomeric DNA binding • mRNA 3'-UTR binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • RNA binding • G-rich strand telomeric DNA binding • identical protein binding • mRNA binding Cydrannau o'r gell • cytoplasm • catalytic step 2 spliceosome • bilen • extracellular region • spliceosomal complex • cnewyllyn cell • nucleoplasm • telomere • Cajal body • nuclear matrix • extracellular exosome • ribonucleoprotein complex Prosesau biolegol • mRNA splicing, via spliceosome • mRNA transport • miRNA transport • RNA transport • mRNA processing • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of mRNA splicing, via spliceosome • GO:1990744, GO:1990729 primary miRNA processing • RNA splicing • G-quadruplex DNA unwinding • positive regulation of telomere maintenance via telomere lengthening • positive regulation of telomerase RNA reverse transcriptase activity • mRNA export from nucleus • RNA metabolic process • interleukin-12-mediated signaling pathway • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3181	n/a
Ensembl	ENSG00000122566	n/a
UniProt	P22626	n/a
RefSeq (mRNA)	NM_002137 NM_031243	n/a
RefSeq (protein)	NP_002128 NP_112533	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HNRNPA2B1 yw HNRNPA2B1 a elwir hefyd yn Heterogeneous nuclear ribonucleoprotein A2/B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p15.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HNRNPA2B1.

• "Perfecting prediction of mutational impact on the aggregation propensity of the ALS-associated hnRNPA2 prion-like protein. ". FEBS Lett. 2017. PMID 28542905.
• "Effects of Mutations on the Aggregation Propensity of the Human Prion-Like Protein hnRNPA2B1. ". Mol Cell Biol. 2017. PMID 28137911.
• "Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion, Growth and Survival. ". Mol Neurobiol. 2016. PMID 25586062.
• "Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer. ". Mol Biosyst. 2015. PMID 25483567.
• "Mechanisms underlying regulation of cell cycle and apoptosis by hnRNP B1 in human lung adenocarcinoma A549 cells.". Tumori. 2014. PMID 24675500.