KMT5A

KMT5A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZKK, 2BQZ, 3F9W, 3F9X, 3F9Y, 3F9Z, 4IJ8, 5HQ2
Dynodwyr
Cyfenwau	KMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07
Dynodwyr allanol	OMIM: 607240 HomoloGene: 41372 GeneCards: KMT5A
EC number	2.1.1.354
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-lysine N-methyltransferase activity • GO:0102674, GO:0102675 methyltransferase activity • GO:0001106 transcription corepressor activity • p53 binding • GO:0001948, GO:0016582 protein binding • transferase activity • lysine N-methyltransferase activity • histone-lysine N-methyltransferase activity • histone methyltransferase activity (H4-K20 specific) Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • Cromosom • cytosol Prosesau biolegol • methylation • GO:0009373 regulation of transcription, DNA-templated • peptidyl-lysine monomethylation • cell cycle • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0045996 negative regulation of transcription, DNA-templated • Cellraniad • transcription, DNA-templated • regulation of DNA damage response, signal transduction by p53 class mediator • histone lysine methylation • regulation of signal transduction by p53 class mediator • histone H4-K20 methylation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	387893	n/a
Ensembl	ENSG00000183955	n/a
UniProt	Q9NQR1	n/a
RefSeq (mRNA)	NM_020382 NM_001324504 NM_001324505 NM_001324506 NM_001367386 NM_001367388 NM_001367389	n/a
RefSeq (protein)	NP_001311433 NP_001311434 NP_001311435 NP_065115 NP_001354315 NP_001354317 NP_001354318	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KMT5A yw KMT5A a elwir hefyd yn Lysine methyltransferase 5A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.31.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KMT5A.

• "SET8 expression is associated with overall survival in gastric cancer. ". Genet Mol Res. 2015. PMID 26634528.
• "SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1. ". EMBO Rep. 2014. PMID 25252681.
• "Functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population. ". Gene. 2017. PMID 28578017.
• "The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling. ". Cell Rep. 2017. PMID 28249161.
• "Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate.". J Mol Biol. 2016. PMID 26953260.