ADRA2A

ADRA2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HLL, 1HO9, 1HOD, 1HOF
Dynodwyr
Cyfenwau	ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, adrenoceptor alpha 2A
Dynodwyr allanol	OMIM: 104210 HomoloGene: 47944 GeneCards: ADRA2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • alpha-2C adrenergic receptor binding • G protein-coupled receptor activity • protein homodimerization activity • epinephrine binding • norepinephrine binding • alpha-1B adrenergic receptor binding • signal transducer activity • adrenergic receptor activity • GO:0001948, GO:0016582 protein binding • alpha2-adrenergic receptor activity • protein heterodimerization activity • thioesterase binding • heterotrimeric G-protein binding • protein kinase binding Cydrannau o'r gell • integral component of membrane • bilen • receptor complex • Cellbilen • integral component of plasma membrane • basolateral plasma membrane • cytoplasm Prosesau biolegol • G protein-coupled receptor signaling pathway • positive regulation of epidermal growth factor-activated receptor activity • activation of protein kinase B activity • negative regulation of insulin secretion • positive regulation of MAP kinase activity • negative regulation of epinephrine secretion • glucose homeostasis • regulation of smooth muscle contraction • GO:0032737 positive regulation of cytokine production • regulation of insulin secretion • positive regulation of cell migration • positive regulation of potassium ion transport • phospholipase C-activating adrenergic receptor signaling pathway • positive regulation of wound healing • negative regulation of norepinephrine secretion • positive regulation of membrane protein ectodomain proteolysis • negative regulation of insulin secretion involved in cellular response to glucose stimulus • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • negative regulation of calcium ion transmembrane transporter activity • cellular response to hormone stimulus • regulation of vasoconstriction • negative regulation of calcium ion-dependent exocytosis • Rho protein signal transduction • positive regulation of cell population proliferation • negative regulation of calcium ion transport • intestinal absorption • Ras protein signal transduction • negative regulation of lipid catabolic process • activation of protein kinase activity • actin cytoskeleton organization • GO:0072468 signal transduction • platelet activation • positive regulation of MAPK cascade • adrenergic receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • receptor transactivation • adenylate cyclase-modulating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	150	n/a
Ensembl	ENSG00000150594	n/a
UniProt	P08913	n/a
RefSeq (mRNA)	NM_000681	n/a
RefSeq (protein)	NP_000672	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADRA2A yw ADRA2A a elwir hefyd yn Adrenoceptor alpha 2A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q25.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADRA2A.

• "Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site. ". Pain. 2017. PMID 27805929.
• "Alpha2A adrenergic receptor genetic variation contributes to hyperglycemia after myocardial infarction. ". Int J Cardiol. 2016. PMID 27131769.
• "ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer. ". Pathol Oncol Res. 2016. PMID 26563278.
• "A Population Based Study of the Genetic Association between Catecholamine Gene Variants and Spontaneous Low-Frequency Fluctuations in Reaction Time. ". PLoS One. 2015. PMID 25978426.
• "The rs10885122 polymorphism of the adrenoceptor alpha 2A (ADRA2A) gene in Euro-Brazilians with type 2 diabetes mellitus.". Arch Endocrinol Metab. 2015. PMID 25926111.