CX3CL1

CX3CL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1B2T, 1F2L, 3ONA, 4XT1, 4XT3
Dynodwyr
Cyfenwau	CX3CL1, ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin, C-X3-C motif chemokine ligand 1
Dynodwyr allanol	OMIM: 601880 HomoloGene: 2251 GeneCards: CX3CL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • chemokine activity • GO:0001948, GO:0016582 protein binding • CCR chemokine receptor binding • signaling receptor binding • integrin binding • CX3C chemokine receptor binding Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • extracellular region • cell surface • extracellular space Prosesau biolegol • G protein-coupled receptor signaling pathway • defense response • positive regulation of inflammatory response • monocyte chemotaxis • cytokine-mediated signaling pathway • chemokine-mediated signaling pathway • angiogenesis involved in wound healing • cellular response to tumor necrosis factor • wound healing • leukocyte chemotaxis • neutrophil chemotaxis • positive regulation of angiogenesis • positive regulation of transforming growth factor beta1 production • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cell adhesion • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • cellular response to interleukin-1 • leukocyte adhesive activation • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cell chemotaxis • lymphocyte chemotaxis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of calcium-independent cell-cell adhesion • chemotaxis • integrin activation • negative regulation of cell migration • leukocyte migration involved in inflammatory response • macrophage chemotaxis • regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6376	n/a
Ensembl	ENSG00000006210	n/a
UniProt	P78423	n/a
RefSeq (mRNA)	NM_002996 NM_001304392	n/a
RefSeq (protein)	NP_001291321 NP_002987	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CX3CL1 yw CX3CL1 a elwir hefyd yn C-X3-C motif chemokine ligand 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q21.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CX3CL1.

• "Rhinovirus induction of fractalkine (CX3CL1) in airway and peripheral blood mononuclear cells in asthma. ". PLoS One. 2017. PMID 28859129.
• "CX3CL1: a potential chemokine widely involved in the process spinal metastases. ". Oncotarget. 2017. PMID 28122354.
• "Reduced CX3CL1 Secretion Contributes to the Susceptibility of Oral Leukoplakia-Associated Fibroblasts to Candida albicans. ". Front Cell Infect Microbiol. 2016. PMID 27891323.
• "Fractalkine/CX3CR1 is involved in the pathogenesis of endometriosis by regulating endometrial stromal cell proliferation and invasion. ". Am J Reprod Immunol. 2016. PMID 27553970.
• "Serum CX3CL1/fractalkine concentrations are positively associated with disease severity in postmenopausal osteoporotic patients.". Br J Biomed Sci. 2016. PMID 27476376.