CUL5

CUL5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3DPL, 3DQV, 4JGH, 4N9F
Dynodwyr
Cyfenwau	CUL5, VACM-1, VACM1, cullin 5, CUL-5
Dynodwyr allanol	OMIM: 601741 HomoloGene: 2597 GeneCards: CUL5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • calcium channel activity • GO:0050372 ubiquitin-protein transferase activity • signaling receptor activity Cydrannau o'r gell • cullin-RING ubiquitin ligase complex • cytosol • Cul5-RING ubiquitin ligase complex • Cul4-RING E3 ubiquitin ligase complex • SCF ubiquitin ligase complex Prosesau biolegol • intrinsic apoptotic signaling pathway • cell population proliferation • ubiquitin-dependent protein catabolic process • negative regulation of cell population proliferation • protein ubiquitination • GO:0022415 viral process • ERBB2 signaling pathway • calcium ion transmembrane transport • cellular response to DNA damage stimulus • post-translational protein modification • G1/S transition of mitotic cell cycle • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8065	n/a
Ensembl	ENSG00000166266	n/a
UniProt	Q93034	n/a
RefSeq (mRNA)	NM_003478	n/a
RefSeq (protein)	NP_003469	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CUL5 yw CUL5 a elwir hefyd yn Cullin 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q22.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CUL5.

• CUL-5
• VACM1
• VACM-1

• "Mutational analysis of VACM-1/cul5 exons in cancer cell lines. ". APMIS. 2011. PMID 21635549.
• "Granulocytic differentiation of HL-60 promyelocytic leukemia cells is associated with increased expression of Cul5. ". In Vitro Cell Dev Biol Anim. 2009. PMID 19118439.
• "Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?". Biochimie. 2016. PMID 26253693.
• "E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells. ". Proc Natl Acad Sci U S A. 2014. PMID 24760825.
• "Downregulation of miR-7 upregulates Cullin 5 (CUL5) to facilitate G1/S transition in human hepatocellular carcinoma cells.". IUBMB Life. 2013. PMID 24339204.