CDH2

CDH2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NCG, 1NCH, 1NCI, 1NCJ, 1OP4, 2QVI, 3Q2W, 4NUM, 4NUP, 4NUQ
Dynodwyr
Cyfenwau	CDH2, CD325, CDHN, CDw325, NCAD, cadherin 2, ACOGS, ARVD14
Dynodwyr allanol	OMIM: 114020 HomoloGene: 20424 GeneCards: CDH2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • gamma-catenin binding • metal ion binding • GO:0001948, GO:0016582 protein binding • enzyme binding • protein phosphatase binding • alpha-catenin binding • protein kinase binding • beta-catenin binding • identical protein binding • cytoskeletal protein binding • protein homodimerization activity • cadherin binding Cydrannau o'r gell • cytoplasm • integral component of membrane • bilen • intercalated disc • cell-cell junction • focal adhesion • plasma membrane raft • adherens junction • Cellbilen • synapse • basolateral plasma membrane • apical plasma membrane • cortical actin cytoskeleton • catenin complex • fascia adherens • extracellular exosome • lamellipodium • GO:0097483, GO:0097481 postsynaptic density • sarcolemma • endoplasmic reticulum lumen • cell surface • cell junction • GO:0005578 extracellular matrix • integral component of plasma membrane • neuron projection • apical part of cell • collagen-containing extracellular matrix • integral component of presynaptic active zone membrane • integral component of postsynaptic specialization membrane Prosesau biolegol • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • blood vessel morphogenesis • homeostasis of number of cells • positive regulation of muscle cell differentiation • regulation of postsynaptic density protein 95 clustering • glial cell differentiation • neuroepithelial cell differentiation • cell-cell adhesion mediated by cadherin • radial glial cell differentiation • neuronal stem cell population maintenance • regulation of oligodendrocyte progenitor proliferation • telencephalon development • neuroligin clustering involved in postsynaptic membrane assembly • positive regulation of synaptic vesicle clustering • cell adhesion • regulation of signal transduction • cerebral cortex development • striated muscle cell differentiation • adherens junction organization • cell migration • negative regulation of canonical Wnt signaling pathway • positive regulation of MAPK cascade • homophilic cell adhesion via plasma membrane adhesion molecules • brain morphogenesis • post-translational protein modification • protein localization to plasma membrane • GO:0000767 cell morphogenesis • cell-cell junction assembly • synapse assembly • regulation of axonogenesis • regulation of synaptic transmission, glutamatergic • cell-cell adhesion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1000	n/a
Ensembl	ENSG00000170558	n/a
UniProt	P19022	n/a
RefSeq (mRNA)	NM_001308176 NM_001792	n/a
RefSeq (protein)	NP_001295105 NP_001783 NP_001783.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDH2 yw CDH2 a elwir hefyd yn Cadherin 2, type 1, N-cadherin (Neuronal), isoform CRA_b a Cadherin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q12.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDH2.

• "Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy. ". Congenit Heart Dis. 2017. PMID 28326674.
• "Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy. ". Circ Cardiovasc Genet. 2017. PMID 28280076.
• "N-Glycosylation at Asn 402 Stabilizes N-Cadherin and Promotes Cell-Cell Adhesion of Glioma Cells. ". J Cell Biochem. 2017. PMID 27864899.
• "N-Cadherin and Fibroblast Growth Factor Receptors crosstalk in the control of developmental and cancer cell migrations. ". Eur J Cell Biol. 2016. PMID 27320194.
• "Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines.". PLoS One. 2016. PMID 27224422.