CCNB1

CCNB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2B9R, 2JGZ, 4Y72, 5HQ0, 4YC3
Dynodwyr
Cyfenwau	CCNB1, CCNB, cyclin B1
Dynodwyr allanol	OMIM: 123836 HomoloGene: 68982 GeneCards: CCNB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • histone kinase activity • kinase activity • patched binding • GO:0001948, GO:0016582 protein binding • cyclin-dependent protein serine/threonine kinase activity • GO:0016534 cyclin-dependent protein serine/threonine kinase activator activity • ubiquitin-like protein ligase binding • protein kinase binding • protein kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity Cydrannau o'r gell • cytoplasm • centrosome • spindle pole • bilen • nucleoplasm • microtubule organizing center • Cytosgerbwd • cnewyllyn cell • cytosol • mitochondrial matrix • cyclin B1-CDK1 complex • cyclin-dependent protein kinase holoenzyme complex Prosesau biolegol • GO:0033128 negative regulation of protein phosphorylation • response to DDT • regulation of mitotic cell cycle spindle assembly checkpoint • positive regulation of mRNA 3'-end processing • tissue regeneration • positive regulation of fibroblast proliferation • cellular response to iron(III) ion • GO:1904579 cellular response to organic cyclic compound • response to mechanical stimulus • positive regulation of mitotic cell cycle • in utero embryonic development • negative regulation of gene expression • regulation of cell cycle • Cellraniad • positive regulation of attachment of spindle microtubules to kinetochore • protein phosphorylation • mitotic nuclear membrane disassembly • cellular response to fatty acid • positive regulation of cardiac muscle cell proliferation • positive regulation of cell cycle • G2/M transition of mitotic cell cycle • oocyte maturation • spermatogenesis • cell cycle • mitotic metaphase plate congression • anaphase-promoting complex-dependent catabolic process • regulation of chromosome condensation • digestive tract development • ventricular cardiac muscle cell development • cellular response to hypoxia • response to toxic substance • GO:0043148 mitotic spindle organization • GO:0007067 Mitosis • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of mitochondrial ATP synthesis coupled electron transport • positive regulation of G2/M transition of mitotic cell cycle • positive regulation of cyclin-dependent protein serine/threonine kinase activity • GO:0034622 protein-containing complex assembly • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of mitotic nuclear division • positive regulation of cell population proliferation • transcription initiation from RNA polymerase II promoter • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	891	n/a
Ensembl	ENSG00000134057	n/a
UniProt	P14635	n/a
RefSeq (mRNA)	NM_031966 NM_001354844 NM_001354845	n/a
RefSeq (protein)	NP_114172 NP_001341773 NP_001341774	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCNB1 yw CCNB1 a elwir hefyd yn G2/mitotic-specific cyclin-B1 a Cyclin B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q13.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCNB1.

• CCNB

• "Activity of cyclin B1 in HL-60 cells treated with etoposide. ". Acta Histochem. 2016. PMID 27297620.
• "Sodium butyrate down-regulates tristetraprolin-mediated cyclin B1 expression independent of the formation of processing bodies. ". Int J Biochem Cell Biol. 2015. PMID 26555753.
• "The Tumor Antigen Cyclin B1 Hosts Multiple CD4 T Cell Epitopes Differently Recognized by Pre-Existing Naive and Memory Cells in Both Healthy and Cancer Donors. ". J Immunol. 2015. PMID 26136431.
• "Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function. ". Int J Biol Markers. 2015. PMID 25982682.
• "Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase.". Cell Cycle. 2014. PMID 25486360.