VGLL3

VGLL3
Identifikatori
Aliasi	VGLL3
Vanjski ID-jevi	OMIM: 609980 MGI: 1920819 HomoloGene: 53442 GeneCards: VGLL3
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	86,991,149 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	65,663,254 bp
Ontologija gena
Molekularna funkcija	• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	389136
	73569
	ENSG00000206538
	ENSMUSG00000091243
	A8MV65
	P85442
	NM_016206; NM_001320493; NM_001320494
	NM_028572; NM_001368760; NM_001368761
	NP_001307422; NP_001307423; NP_057290
	NP_082848; NP_001355689; NP_001355690
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 3 porodice rudimentolikih proteina jest protein koji je kod ljudi kodiran genom VGLL3 sa hromosoma 3.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 326 aminokiselina, а molekulska težina 36.009 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSCAEVMYHP	QPYGASQYLP	NPMAATTCPT	AYYQPAPQPG	QQKKLAVFSK
MQDSLEVTLP	SKQEEEDEEE	EEEEKDQPAE	MEYLNSRCVL	FTYFQGDIGS
VVDEHFSRAL	GQAITLHPES	AISKSKMGLT	PLWRDSSALS	SQRNSFPTSF
WTSSYQPPPA	PCLGGVHPDF	QVTGPPGTFS	AADPSPWPGH	NLHQTGPAPP
PAVSESWPYP	LTSQVSPSYS	HMHDVYMRHH	HPHAHMHHRH	RHHHHHHHPP
AGSALDPSYG	PLLMPSVHAA	RIPAPQCDIT	KTEPTTVTSA	TSAWAGAFHG
TVDIVPSVGF	DTGLQHQDKS	KESPWY

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000206538 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000091243 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Vestigial-like family member 3".
^ "UniProt, A8MV65" (jezik: engleski). Pristupljeno 6. 11. 2021.

Dopunska literatura

Tao S, Wang Z, Feng J, Hsu FC, Jin G, Kim ST, Zhang Z, Gronberg H, Zheng LS, Isaacs WB, Xu J, Sun J (mart 2012). "A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants". Carcinogenesis. 33 (3): 598–603. doi:10.1093/carcin/bgr316. PMC 3291863. PMID 22219177.
Gambaro K, Quinn MC, Wojnarowicz PM, Arcand SL, de Ladurantaye M, Barrès V, Ripeau JS, Killary AM, Davis EC, Lavoie J, Provencher DM, Mes-Masson AM, Chevrette M, Tonin PN (juni 2013). "VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer". Molecular Oncology. 7 (3): 513–30. doi:10.1016/j.molonc.2012.12.006. PMC 5528482. PMID 23415753.
Zhou W, Chen H, Zhang L (mart 2009). "The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor". BMB Reports. 42 (3): 154–9. doi:10.5483/bmbrep.2009.42.3.154. PMID 19336002.
Halperin DS, Pan C, Lusis AJ, Tontonoz P (februar 2013). "Vestigial-like 3 is an inhibitor of adipocyte differentiation". Journal of Lipid Research. 54 (2): 473–81. doi:10.1194/jlr.M032755. PMC 3541706. PMID 23152581.
Hélias-Rodzewicz Z, Pérot G, Chibon F, Ferreira C, Lagarde P, Terrier P, Coindre JM, Aurias A (decembar 2010). "YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas". Genes, Chromosomes & Cancer. 49 (12): 1161–71. doi:10.1002/gcc.20825. PMID 20842732. S2CID 205828045.
Wang L, Lu W, Chen YG, Zhou XM, Gu JR (decembar 1999). "Comparison of gene expression between normal colon mucosa and colon carcinoma by means of messenger RNA differential display". World Journal of Gastroenterology. 5 (6): 533–534. doi:10.3748/wjg.v5.i6.533. PMC 4688801. PMID 11819507.
Maeda T, Chapman DL, Stewart AF (decembar 2002). "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation". The Journal of Biological Chemistry. 277 (50): 48889–98. doi:10.1074/jbc.M206858200. PMID 12376544.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000206538 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000091243 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Vestigial-like family member 3".

[UniProt-6] "UniProt, A8MV65" (jezik: engleski). Pristupljeno 6. 11. 2021.

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