VNN1

VNN1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4CYF, 4CYG, 4CYY
Identifikatori
Aliasi	VNN1
Vanjski ID-jevi	MGI: 108395 HomoloGene: 32130 GeneCards: VNN1
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	132,714,055 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	23,781,241 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; • hydrolase activity; • pantetheine hydrolase activity;
Ćelijska komponenta	• integral component of membrane; • membrana; • anchored component of membrane; • extracellular region; • ćelijska membrana; • azurophil granule membrane;
Biološki proces	• positive regulation of T cell differentiation in thymus; • GO:0001306 response to oxidative stress; • nitrogen compound metabolic process; • acute inflammatory response; • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; • Urođeni imunski sistem; • inflammatory response; • chronic inflammatory response; • pantothenate metabolic process; • neutrophil degranulation; • cell-cell adhesion;
	Izvori:Amigo / QuickGO
Ortolozi
	8876
	22361
	ENSG00000112299
	ENSMUSG00000037440
	O95497
	Q9Z0K8
	NM_004666
	NM_011704
	NP_004657
	NP_035834
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Panteteinaza jest enzim koji je kod ljudi kodiran genom VNN1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 513 aminokiselina, а molekulska težina 57.012 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTTQLPAYVA	ILLFYVSRAS	CQDTFTAAVY	EHAAILPNAT	LTPVSREEAL
ALMNRNLDIL	EGAITSAADQ	GAHIIVTPED	AIYGWNFNRD	SLYPYLEDIP
DPEVNWIPCN	NRNRFGQTPV	QERLSCLAKN	NSIYVVANIG	DKKPCDTSDP
QCPPDGRYQY	NTDVVFDSQG	KLVARYHKQN	LFMGENQFNV	PKEPEIVTFN
TTFGSFGIFT	CFDILFHDPA	VTLVKDFHVD	TIVFPTAWMN	VLPHLSAVEF
HSAWAMGMRV	NFLASNIHYP	SKKMTGSGIY	APNSSRAFHY	DMKTEEGKLL
LSQLDSHPSH	SAVVNWTSYA	SSIEALSSGN	KEFKGTVFFD	EFTFVKLTGV
AGNYTVCQKD	LCCHLSYKMS	ENIPNEVYAL	GAFDGLHTVE	GRYYLQICTL
LKCKTTNLNT	CGDSAETAST	RFEMFSLSGT	FGTQYVFPEV	LLSENQLAPG
EFQVSTDGRL	FSLKPTSGPV	LTVTLFGRLY	EKDWASNASS	GLTAQARIIM
LIVIAPIVCS	LSW

Funkcija

Ovaj genski proizvod je član vaninske porodice proteina koji međusobno dijele veliku sličnost sekvenci, kao i sa biotinidazom. Porodica uključuje izlučene i membranom povezane proteine, od kojih je nekoliko prijavljeno da učestvuju u prometu hematopoetskih ćelija. Nijedna biotinidazna aktivnost nije dokazana ni za jedan od vaninski proteina; međutim, oni posjeduju panteteinaznu aktivnost, koja može imati ulogu u odgovoru na oksidativni stres. Ovaj protein, kao i njegov mišji homolog, vjerovatno je GPI usidrena molekula ćelijske površine. Mišji protein eksprimiraju perivaskularne timusne stromske ćelije i reguliraju migraciju progenitornih T-ćelija u timus. Ovaj gen je u neposrednoj blizini i u istoj transkripcijskoj orijentaciji kao i dva druga gena vanina na hromosomu 6q, regija 23-q24.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112299 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037440 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.
^ ^a ^b "Entrez Gene: VNN1 vanin 1".
^ "UniProt, O95497" (jezik: engleski). Pristupljeno 11. 10. 2021.

Dopunska literatura

Aurrand-Lions M, Galland F, Bazin H, et al. (1997). "Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing". Immunity. 5 (5): 391–405. doi:10.1016/S1074-7613(00)80496-3. PMID 8934567.
Maras B, Barra D, Duprè S, Pitari G (1999). "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?". FEBS Lett. 461 (3): 149–52. doi:10.1016/S0014-5793(99)01439-8. PMID 10567687. S2CID 25738323.
Martin F, Malergue F, Pitari G, et al. (2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533. S2CID 10763223.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kristiansen TZ, Bunkenborg J, Gronborg M, et al. (2005). "A proteomic analysis of human bile". Mol. Cell. Proteomics. 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Min-Oo G, Fortin A, Pitari G, et al. (2007). "Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus". J. Exp. Med. 204 (3): 511–24. doi:10.1084/jem.20061252. PMC 2137903. PMID 17312006.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112299 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037440 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9790769-5] Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.

[entrez-6] "Entrez Gene: VNN1 vanin 1".

[UniProt-7] "UniProt, O95497" (jezik: engleski). Pristupljeno 11. 10. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak