TICAM2

TICAM2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2M1W
Identifikatori
Aliasi	TICAM2
Vanjski ID-jevi	OMIM: 608321 MGI: 3040056 HomoloGene: 11014 GeneCards: TICAM2
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	115,602,479 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	46,707,600 bp
Ontologija gena
Molekularna funkcija	• signal transducer activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • endozom; • late endosome; • Golđijev aparat; • early endosome membrane; • membrana; • late endosome membrane; • ćelijska membrana; • early endosome; • Endoplazmatski retikulum; • endosome membrane; • secretory granule membrane;
Biološki proces	• toll-like receptor 4 signaling pathway; • negative regulation of chemokine (C-C motif) ligand 5 production; • immune system process; • TRAM-dependent toll-like receptor 4 signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • positive regulation of toll-like receptor 4 signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • inflammatory response; • cellular response to lipopolysaccharide; • I-kappaB kinase/NF-kappaB signaling; • negative regulation of toll-like receptor 4 signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • GO:0072468 Transdukcija signala; • GO:0060554, GO:0060555 necroptosis; • apoptotic signaling pathway; • negative regulation of MyD88-independent toll-like receptor signaling pathway; • Urođeni imunski sistem; • neutrophil degranulation; • positive regulation of chemokine (C-C motif) ligand 5 production; • positive regulation of interleukin-18-mediated signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	353376
	225471
	ENSG00000243414
	ENSMUSG00000056130
	Q86XR7
	Q8BJQ4
	NM_021649
	NM_173394
	NP_067681; NP_001157940; NP_001157941
	NP_775570
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Adapterska molekula 2 sa domenom TIR je protein koji je kod ljudi kodiran genom TICAM2.^[5]

TIRP je toll/interleukinski-1 receptor (IL1R; MIM 147810) (TIR) adapterski prptein sa domenom, uključenim u signalizaciju Toll-receptora (vidi: TLR4; MIM 603030; prema OMIM)^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 235 aminokiselina, a molekulska težina Da. 26 916^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGIGKSKINS	CPLSLSWGKR	HSVDTSPGYH	ESDSKKSEDL	SLCNVAEHSN
TTEGPTGKQE	GAQSVEEMFE	EEAEEEVFLK	FVILHAEDDT	DEALRVQNLL
QDDFGIKPGI	IFAEMPCGRQ	HLQNLDDAVN	GSAWTILLLT	ENFLRDTWCN
FQFYTSLMNS	VNRQHKYNSV	IPMRPLNNPL	PRERTPFALQ	TINALEEESR
GFPTQVERIF	QESVYKTQQT	IWKETRNMVQ	RQFIA

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000243414 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056130 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2".
^ "UniProt, Q86XR7" (jezik: англ.). Pristupljeno 15. 10. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Sullivan C, Postlethwait JH, Lage CR, et al. (2007). "Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates". J. Immunol. 178 (7): 4517–27. doi:10.4049/jimmunol.178.7.4517. PMID 17372010.
Rowe DC, McGettrick AF, Latz E, et al. (2006). "The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6299–304. doi:10.1073/pnas.0510041103. PMC 1458872. PMID 16603631.
Yamamoto M, Sato S, Hemmi H, et al. (2003). "TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway". Nat. Immunol. 4 (11): 1144–50. doi:10.1038/ni986. PMID 14556004. S2CID 13016860.
Oshiumi H, Sasai M, Shida K, et al. (2004). "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta". J. Biol. Chem. 278 (50): 49751–62. doi:10.1074/jbc.M305820200. PMID 14519765.
Fitzgerald KA, Rowe DC, Barnes BJ, et al. (2003). "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

V anjski linkovi

Q86XR7

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000243414 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056130 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2".

[UniProt-6] "UniProt, Q86XR7" (jezik: англ.). Pristupljeno 15. 10. 2021.CS1 održavanje: nepoznati jezik (link)

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