PTPN14

PTPN14
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2BZL
Identifikatori
Aliasi	PTPN14
Vanjski ID-jevi	OMIM: 603155 MGI: 102467 HomoloGene: 3941 GeneCards: PTPN14
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	214,552,449 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	189,608,892 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• phosphoprotein phosphatase activity; • hydrolase activity; • GO:0098519, GO:0098518 phosphatase activity; • receptor tyrosine kinase binding; • GO:0001104 transcription coregulator activity; • GO:0001948, GO:0016582 vezivanje za proteine; • protein tyrosine phosphatase activity;
Ćelijska komponenta	• jedro; • citoplazma; • citoskelet; • nukleoplazma;
Biološki proces	• negative regulation of cell population proliferation; • GO:0009373 regulation of transcription, DNA-templated; • GO:0016576 protein dephosphorylation; • regulation of protein export from nucleus; • transcription, DNA-templated; • GO:0098501, GO:0098502, GO:0006286 Defosforilacija; • lymphangiogenesis; • peptidyl-tyrosine dephosphorylation; • cellular response to cytokine stimulus; • regulation of nucleic acid-templated transcription;
	Izvori:Amigo / QuickGO
Ortolozi
	5784
	19250
	ENSG00000152104
	ENSMUSG00000026604
	Q15678
	Q62130
	NM_005401
	NM_001033287; NM_008976
	NP_005392
	NP_033002
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Tirozin-protein fosfataza nereceptorski tip 14 jest enzim koji je kod ljudi kodiran genom PTPN14 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.187 aminokiselina, a molekulska težina 135.261 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPFGLKLRRT	RRYNVLSKNC	FVTRIRLLDS	NVIECTLSVE	STGQECLEAV
AQRLELRETH	YFGLWFLSKS	QQARWVELEK	PLKKHLDKFA	NEPLLFFGVM
FYVPNVSWLQ	QEATRYQYYL	QVKKDVLEGR	LRCTLDQVIR	LAGLAVQADF
GDYNQFDSQD	FLREYVLFPM	DLALEEAVLE	ELTQKVAQEH	KAHSGILPAE
AELMYINEVE	RLDGFGQEIF	PVKDNHGNCV	HLGIFFMGIF	VRNRIGRQAV
IYRWNDMGNI	THNKSTILVE	LINKEETALF	HTDDIENAKY	ISRLFATRHK
FYKQNKICTE	QSNSPPPIRR	QPTWSRSSLP	RQQPYILPPV	HVQCGEHYSE
THTSQDSIFH	GNEEALYCNS	HNSLDLNYLN	GTVTNGSVCS	VHSVNSLNCS
QSFIQASPVS	SNLSIPGSDI	MRADYIPSHR	HSAIIVPSYR	PTPDYETVMR
QMKRGILHTD	SQSQSLRNLN	IINTHAYNQP	EDLVYSQPEM	RERHPYTVPY
GPQGVYSNKL	VSPSDQRNPK	NNVVPSKPGA	SAISHTVSTP	ELANMQLQGS
HNYSTAHMLK	NYLFRPPPPY	PRPRPATSTP	DLASHRHKYV	SGSSPDLVTR
KVQLSVKTFQ	EDSSPVVHQS	LQEVSEPLTA	TKHHGTVNKR	HSLEVMNSMV
RGMEAMTLKS	LHLPMARRNT	LREQGPPEEG	SGSHEVPQLP	QYHHKKTFSD
ATMLIHSSES	EEEEEEAPES	VPQIPMLREK	MEYSAQLQAA	LARIPNKPPP
EYPGPRKSVS	NGALRQDQAS	LPPAMARARV	LRHGPAKAIS	MSRTDPPAVN
GASLGPSISE	PDLTSVKERV	KKEPVKERPV	SEMFSLEDSI	IEREMMIRNL
EKQKMAGLEA	QKRPLMLAAL	NGLSVARVSG	REENRVDATR	VPMDERFRTL
KKKLEEGMVF	TEYEQIPKKK	ANGIFSTAAL	PENAERSRIR	EVVPYEENRV
ELIPTKENNT	GYINASHIKV	VVGGAEWHYI	ATQGPLPHTC	HDFWQMVWEQ
GVNVIAMVTA	EEEGGRTKSH	RYWPKLGSKH	SSATYGKFKV	TTKFRTDSVC
YATTGLKVKH	LLSGQERTVW	HLQYTDWPDH	GCPEDVQGFL	SYLEEIQSVR
RHTNSMLEGT	KNRHPPIVVH	CSAGVGRTGV	LILSELMIYC	LEHNEKVEVP
MMLRLLREQR	MFMIQTIAQY	KFVYQVLIQF	LQNSRLI

Funkcija

Protein kodiran ovim genom član je porodice PTP i PTPN14 Arhivirano 17. 12. 2021. na Wayback Machine potporodice tirozin protein-fosfataza. Poznato je da su PTP-ovi signalne molekule koje regulišu različite ćelijske procese, uključujući rast ćelije, diferencijaciju, mitotski ciklus i onkogenu transformaciju. Ovaj PTP sadrži N-terminalni nekatalitski domen sličnan onom kod proteina koji su povezani sa natporodicom citoskeletnih traka 4.1, što ukazuje na lokalizaciju ovog proteina na membrani ili citoskeletu. Specifična funkcija ovog PTP-a još nije utvrđena.^[6]

Interakcije

Pokazalo se da PTPN14 reaguje sa beta-kateninom.^[8]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152104 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026604 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR (Apr 1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochemical and Biophysical Research Communications. 209 (3): 959–65. doi:10.1006/bbrc.1995.1591. PMID 7733990.
^ ^a ^b "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14".
^ "UniProt, Q15678" (jezik: engleski). Pristupljeno 16. 12. 2021.
^ Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.

Dopunska literatura

Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J (Jun 1994). "The 1993-94 Généthon human genetic linkage map". Nature Genetics. 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID 7545953. S2CID 24662426.
Ogata M, Takada T, Mori Y, Oh-hora M, Uchida Y, Kosugi A, Miyake K, Hamaoka T (Apr 1999). "Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells". The Journal of Biological Chemistry. 274 (18): 12905–9. doi:10.1074/jbc.274.18.12905. PMID 10212280.
Ogata M, Takada T, Mori Y, Uchida Y, Miki T, Okuyama A, Kosugi A, Sawada M, Oh-hora M, Hamaoka T (Jul 1999). "Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion". The Journal of Biological Chemistry. 274 (29): 20717–24. doi:10.1074/jbc.274.29.20717. PMID 10400706.
Aoyama K, Matsuda T, Aoki N (Dec 1999). "Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36". Biochemical and Biophysical Research Communications. 266 (2): 523–31. doi:10.1006/bbrc.1999.1845. PMID 10600535.
Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Sep 2000). "Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation". Journal of Cell Science. 113 ( Pt 17) (17): 3117–23. doi:10.1242/jcs.113.17.3117. hdl:2440/9579. PMID 10934049.
Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Barr AJ, Debreczeni JE, Eswaran J, Knapp S (Jun 2006). "Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution". Proteins. 63 (4): 1132–6. doi:10.1002/prot.20958. PMID 16534812. S2CID 7186900.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi

PDBe-KB provides an overview of all the structure information available in the PDB for Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14)

Vanjski linkovi

Šablon:Protein tirozin-fosfataze

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152104 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026604 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7733990-5] Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR (Apr 1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochemical and Biophysical Research Communications. 209 (3): 959–65. doi:10.1006/bbrc.1995.1591. PMID 7733990.

[entrez-6] "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14".

[UniProt-7] "UniProt, Q15678" (jezik: engleski). Pristupljeno 16. 12. 2021.

[pmid12808048-8] Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak