INTS1

INTS1
Identifikatori
Aliasi	INTS1
Vanjski ID-jevi	OMIM: 611345 MGI: 1915760 HomoloGene: 53111 GeneCards: INTS1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	1,504,389 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	139,761,429 bp
Ortolozi
	26173
	68510
	ENSG00000164880
	ENSMUSG00000029547
	Q8N201
	Q6P4S8
	NM_001080453
	NM_026748
	NP_001073922
	NP_081024
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica 1 kompleksa integriranja je protein koji je kod ljudi kodiran genom INTS1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 2.190 aminokiselina, а molekulska težina 244.297 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNRAKPTTVR	RPSAAAKPSG	HPPPGDFIAL	GSKGQANESK	TASTLLKPAP
SGLPSERKRD	AAAALSSASA	LTGLTKRPKL	SSTPPLSALG	RLAEAAVAEK
RAISPSIKEP	SVVPIEVLPT	VLLDEIEAAE	LEGNDDRIEG	VLCGAVKQLK
VTRAKPDSTL	YLSLMYLAKI	KPNIFATEGV	IEALCSLLRR	DASINFKAKG
NSLVSVLACN	LLMAAYEEDE	NWPEIFVKVY	IEDSLGERIW	VDSPHCKTFV
DNIQTAFNTR	MPPRSVLLQG	EAGRVAGDLG	AGSSPHPSLT	EEEDSQTELL
IAEEKLSPEQ	EGQLMPRYEE	LAESVEEYVL	DMLRDQLNRR	QPIDNVSRNL
LRLLTSTCGY	KEVRLLAVQK	LEMWLQNPKL	TRPAQDLLMS	VCMNCNTHGS
EDMDVISHLI	KIRLKPKVLL	NHFMLCIREL	LSAHKDNLGT	TIKLVIFNEL
SSARNPNNMQ	VLYTALQHSS	ELAPKFLAMV	FQDLLTNKDD	YLRASRALLR
EIIKQTKHEI	NFQAFCLGLM	QERKEPQYLE	MEFKERFVVH	ITDVLAVSMM
LGITAQVKEA	GIAWDKGEKR	NLEVLRSFQN	QIAAIQRDAV	WWLHTVVPSI
SKLAPKDYVH	CLHKVLFTEQ	PETYYKWDNW	PPESDRNFFL	RLCSEVPILE
DTLMRILVIG	LSRELPLGPA	DAMELADHLV	KRAAAVQADD	VEVLKVGRTQ
LIDAVLNLCT	YHHPENIQLP	PGYQPPNLAI	STLYWKAWPL	LLVVAAFNPE
NIGLAAWEEY	PTLKMLMEMV	MTNNYSYPPC	TLTDEETRTE	MLNRELQTAQ
REKQEILAFE	GHLAAASTKQ	TITESSSLLL	SQLTSLDPQG	PPRRPPPHIL
DQVKSLNQSL	RLGHLLCRSR	NPDFLLHIIQ	RQASSQSMPW	LADLVQSSEG
SLDVLPVQCL	CEFLLHDAVD	DAASGEEDDE	GESKEQKAKK	RQRQQKQRQL
LGRLQDLLLG	PKADEQTTCE	VLDYFLRRLG	SSQVASRVLA	MKGLSLVLSE
GSLRDGEEKE	PPMEEDVGDT	DVLQGYQWLL	RDLPRLPLFD	SVRSTTALAL
QQAIHMETDP	QTISAYLIYL	SQHTPVEEQA	QHSDLALDVA	RLVVERSTIM
SHLFSKLSPS	AASDAVLSAL	LSIFSRYVRR	MRQSKEGEEV	YSWSESQDQV
FLRWSSGETA	TMHILVVHAM	VILLTLGPPR	ADDSEFQALL	DIWFPEEKPL
PTAFLVDTSE	EALLLPDWLK	LRMIRSEVLR	LVDAALQDLE	PQQLLLFVQS
FGIPVSSMSK	LLQFLDQAVA	HDPQTLEQNI	MDKNYMAHLV	EVQHERGASG
GQTFHSLLTA	SLPPRRDSTE	APKPKSSPEQ	PIGQGRIRVG	TQLRVLGPED
DLAGMFLQIF	PLSPDPRWQS	SSPRPVALAL	QQALGQELAR	VVQGSPEVPG
ITVRVLQALA	TLLSSPHGGA	LVMSMHRSHF	LACPLLRQLC	QYQRCVPQDT
GFSSLFLKVL	LQMLQWLDSP	GVEGGPLRAQ	LRMLASQASA	GRRLSDVRGG
LLRLAEALAF	RQDLEVVSST	VRAVIATLRS	GEQCSVEPDL	ISKVLQGLIE
VRSPHLEELL	TAFFSATADA	ASPFPACKPV	VVVSSLLLQE	EEPLAGGKPG
ADGGSLEAVR	LGPSSGLLVD	WLEMLDPEVV	SSCPDLQLRL	LFSRRKGKGQ
AQVPSFRPYL	LTLFTHQSSW	PTLHQCIRVL	LGKSREQRFD	PSASLDFLWA
CIHVPRIWQG	RDQRTPQKRR	EELVLRVQGP	ELISLVELIL	AEAETRSQDG
DTAACSLIQA	RLPLLLSCCC	GDDESVRKVT	EHLSGCIQQW	GDSVLGRRCR
DLLLQLYLQR	PELRVPVPEV	LLHSEGAASS	SVCKLDGLIH	RFITLLADTS
DSRALENRGA	DASMACRKLA	VAHPLLLLRH	LPMIAALLHG	RTHLNFQEFR
QQNHLSCFLH	VLGLLELLQP	HVFRSEHQGA	LWDCLLSFIR	LLLNYRKSSR
HLAAFINKFV	QFIHKYITYN	APAAISFLQK	HADPLHDLSF	DNSDLVMLKS
LLAGLSLPSR	DDRTDRGLDE	EGEEESSAGS	LPLVSVSLFT	PLTAAEMAPY
MKRLSRGQTV	EDLLEVLSDI	DEMSRRRPEI	LSFFSTNLQR	LMSSAEECCR
NLAFSLALRS	MQNSPSIAAA	FLPTFMYCLG	SQDFEVVQTA	LRNLPEYALL
CQEHAAVLLH	RAFLVGMYGQ	MDPSAQISEA	LRILHMEAVM

Funkcija

INTS1 je podjedinica integratorskog kompleksa, koja se povezuje sa C-terminalnim domenom velike podjedinice RNK-polimeraze II (POLR2A; MIM 180660) i posreduje u 3' završnoj obradi malih jedarnih RNK U1 (RNU1; MIM 180680) i U2 (RNU2; MIM 180690) (Baillat et al., 2005 PubMed 16239144]).

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164880 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029547 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Integrator complex subunit 1". Pristupljeno 25. 9. 2021.
^ "HUGO Gene Nomenclature Commitee, HGNC:24555" (jezik: англ.). Pristupljeno 25. 9. 2021.CS1 održavanje: nepoznati jezik (link)^{[mrtav link]}
^ "UniProt, Q8N201" (jezik: engleski). Pristupljeno 25. 9. 2021.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164880 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029547 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Integrator complex subunit 1". Pristupljeno 25. 9. 2021.

[HGNC-6] "HUGO Gene Nomenclature Commitee, HGNC:24555" (jezik: англ.). Pristupljeno 25. 9. 2021.CS1 održavanje: nepoznati jezik (link)^{[mrtav link]}

[UniProt-7] "UniProt, Q8N201" (jezik: engleski). Pristupljeno 25. 9. 2021.

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